In the present study, low molecular weight poly(propylene carbonate) (PPC, Mn = 3500), a biodegradable liquid polymer easily prepared from carbon dioxide (CO2), was modified into poly(propylene carbonate)diacrylate (PPC-DA) by acylation, and methoxy poly(ethylene glycol) (mPEG) was modified into methoxy poly(ethylene glycol) acrylate (mPEG-A). Using PPC-DA as the dispersant to dissolve hydrophobic doxorubicin (DOX) and the initiator, and with mPEG-A as the co-monomer and polymerisable surfactant, a biodegradable nanodrug with excellent biocompatibility was prepared by shear emulsification polymerization without surfactants or organic solvent residues. The nanodrug can be efficiently endocytosed by tumor cells and can rapidly release doxorubicin triggered by the acidic endosomal pH. As evidenced by experiments in tumor-bearing mice, such a nanodrug is stealthy during blood circulation, and targets tumor sites with high efficiency. Moreover, this nanodrug is more effective and less toxic than free doxorubicin. This study provides a green and versatile approach for preparing biodegradable nanodrugs via a simple and efficient process. Moreover, this study extends the applications of CO2 based polymers in the biomedical field, promoting the development of CO2 polymerization fixation.

中文翻译：

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通过一锅无表面活性剂和无溶剂的细乳液制备可生物降解的基于CO2的聚合物抗肿瘤纳米药物。

在本研究中，低分子量聚碳酸亚丙酯（PPC，Mn = 3500）是一种很容易由二氧化碳（CO2）制得的可生物降解的液态聚合物，通过酰化改性为聚碳酸亚丙酯（PPC-DA） ，并且将甲氧基聚（乙二醇）（mPEG）改性为甲氧基聚（乙二醇）丙烯酸酯（mPEG-A）。以PPC-DA为分散剂溶解疏水性阿霉素（DOX）和引发剂，并以mPEG-A为共聚单体和可聚合表面活性剂，通过剪切乳化聚合制备了具有良好生物相容性的可生物降解的纳米药物，而没有表面活性剂或有机溶剂残留。纳米药物可以被肿瘤细胞有效地内吞，并且可以由酸性内体pH触发快速释放阿霉素。实验证明，荷瘤小鼠 这种纳米药物在血液循环中是隐身的，并且可以高效地靶向肿瘤部位。此外，这种纳米药物比游离阿霉素更有效且毒性更低。这项研究提供了一种绿色且用途广泛的方法，可通过一种简单而有效的方法来制备可生物降解的纳米药物。此外，这项研究扩展了基于CO2的聚合物在生物医学领域的应用，促进了CO2聚合固定的发展。