Direct analysis of Na, K, Mg and Ca in human saliva and correlations with physiological conditions,Analytical Methods

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Direct analysis of Na, K, Mg and Ca in human saliva and correlations with physiological conditions
Analytical Methods ( IF 2.7 ) Pub Date : 2020-02-19 , DOI: 10.1039/d0ay00203h
Felipe Dias dos Reis _{1,

2,

3,

4} , Olavo dos Santos Pereira Júnior _{2,

3,

4,

5} , Rafael Arromba de Sousa _{1,

2,

3,

4}

Affiliation

Saliva is a biological fluid composed of several organic and inorganic compounds. Its rich composition, due to a complex formation process, allows saliva to be an important biological fluid for collecting information from an organism. Organic compounds have been largely studied and the correlation of their levels with physiological conditions are well reported in the literature. In this context, the aim of the present study was to investigate the mineral composition of saliva (Mg, Ca, Na and K in 109 individuals) in order to discover correlations with physiological conditions, such as biological gender, blood glucose disorders, osteoporosis, heart palpitations, decreased muscular mass and unintentional weight loss. A sample preparation study was carried on and direct analysis was chosen due to its many advantages over acid digestion. The results showed that the levels of the analytes varied largely and presented no identified patterns. However, through boxplot analysis, some statistical differences and correlations with physiological conditions could be found. In addition, 30 saliva samples of renal patients were collected in order to investigate variations in the levels of the analytes before and after hemodialysis. The results showed that the variations tended to form a pattern, which indicated a possible correlation between the hemodialysis procedure and these specific ions in human saliva.

中文翻译：

直接分析唾液中的Na，K，Mg和Ca及其与生理状况的关系

唾液是由几种有机和无机化合物组成的生物流体。由于形成过程复杂，其丰富的成分使唾液成为从生物体收集信息的重要生物流体。已经对有机化合物进行了大量研究，并且其水平与生理条件的相关性在文献中已有很好的报道。在此背景下，本研究的目的是调查唾液的矿物质成分（109个人中的Mg，Ca，Na和K），以发现与生理状况的相关性，例如生理性别，血糖异常，骨质疏松，心，肌肉减少和无意的体重减轻。进行了样品前处理研究，并选择了直接分析方法，原因是它比酸消解法具有许多优势。结果表明，分析物的水平变化很大，没有发现任何模式。然而，通过箱线图分析，可以发现一些统计差异和与生理状况的相关性。此外，收集了30例肾病患者的唾液样本，以调查血液透析前后分析物水平的变化。结果表明，这种变化趋于形成一种模式，这表明血液透析程序与人唾液中这些特定离子之间可能存在相关性。收集了30位肾病患者的唾液样本，以研究血液透析前后分析物水平的变化。结果表明，这种变化趋于形成一种模式，这表明血液透析程序与人唾液中这些特定离子之间可能存在相关性。收集了30位肾病患者的唾液样本，以研究血液透析前后分析物水平的变化。结果表明，这种变化趋于形成一种模式，这表明血液透析程序与人唾液中这些特定离子之间可能存在相关性。

更新日期：2020-02-19

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