Cascade substitution reaction between oxabornene and amines to construct cyclohexa‐1,4‐diene‐3,6‐diamine and amino alcohol,Journal of Heterocyclic Chemistry

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Cascade substitution reaction between oxabornene and amines to construct cyclohexa‐1,4‐diene‐3,6‐diamine and amino alcohol
Journal of Heterocyclic Chemistry ( IF 2.0 ) Pub Date : 2020-02-19 , DOI: 10.1002/jhet.3917
Changkuo Zhao ₁ , Xianheng Wang ₁ , Lang Xu ₁ , Ying Cao ₁ , Hanqi Cui ₁ , Yuhe Wang ₂

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In competition with Michael addition between oxabornene and amines, a cascade substitution reaction predominates to generate cyclohexa‐1,4‐diene‐3,6‐diamine and amino alcohol in a moderate yield. This method has wide universality for different amines, overcomes the shortcomings of Michael addition reaction that cannot be synthesized due to shortage of raw materials, and can be further applied to the total synthesis of some related natural products.

中文翻译：

氧杂冰片与胺之间的级联取代反应以构建环己-1,4-二烯-3,6-二胺和氨基醇

在与氧杂冰片烯和胺之间的迈克尔加成反应中，级联取代反应占主导地位，以中等收率生成环己-1,4-二烯-3,6-二胺和氨基醇。该方法对不同的胺类具有广泛的通用性，克服了由于原料不足而无法合成的迈克尔加成反应的缺点，可进一步应用于某些相关天然产物的全合成。

更新日期：2020-02-19

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