Observational versus antibiotic treatment for uncomplicated diverticulitis: an individual-patient data meta-analysis.,British Journal of Surgery

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Observational versus antibiotic treatment for uncomplicated diverticulitis: an individual-patient data meta-analysis.
British Journal of Surgery ( IF 8.6 ) Pub Date : 2020-02-19 , DOI: 10.1002/bjs.11465
S T van Dijk ₁ , A Chabok ₂ , M G Dijkgraaf ₃ , M A Boermeester ₁ , K Smedh ₂

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Two RCTs (AVOD and DIABOLO) demonstrated no difference in recovery or adverse outcomes when antibiotics for acute uncomplicated diverticulitis were omitted. Both trials showed non‐significantly higher rates of complicated diverticulitis and surgery in the non‐antibiotic groups. This meta‐analysis of individual‐patient data aimed to explore adverse outcomes and identify patients at risk who may benefit from antibiotic treatment.

中文翻译：

单纯性憩室炎的观察性治疗与抗生素治疗：一项个体患者数据荟萃分析。

当省略用于急性单纯性憩室炎的抗生素时，两个RCT（AVOD和DIABOLO）显示出恢复或不良结局无差异。两项试验均显示非抗生素组的复杂憩室炎和手术的发生率非明显增加。这项对个人患者数据的荟萃分析旨在探讨不良结局并确定可能从抗生素治疗中受益的高危患者。

更新日期：2020-02-19

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