Capicua, encoded by the gene CIC, is an evolutionarily conserved high-mobility group-box transcription factor downstream of the receptor tyrosine kinase and mitogen-activated protein kinase pathways. It was initially discovered and studied in Drosophila. Recurrent mutations in CIC were first identified in oligodendroglioma, a subtype of low-grade glioma. Subsequent studies have identified CIC aberrations in multiple types of cancer and have established CIC as a potent tumour suppressor involved in regulating pathways related to cell growth and proliferation, invasion and treatment resistance. The most well-known and studied targets of mammalian CIC are the oncogenic E-Twenty Six transcription factors ETV1/4/5, which have been found to be elevated in cancers with CIC aberrations. Here, we review the role of CIC in normal mammalian development, oncogenesis and tumour progression, and the functional interactors that mediate them. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

中文翻译：

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制造头或尾-capicua（CIC）作为一种重要的多功能抑癌剂的出现。

由基因CIC编码的Capicua是受体酪氨酸激酶和促分裂原激活的蛋白激酶途径下游的进化保守的高迁移率基盒转录因子。它最初是在果蝇中发现和研究的。CIC的复发突变首先在低度神经胶质瘤亚型少突胶质细胞瘤中发现。随后的研究已经确定了多种类型癌症中的CIC畸变，并已将CIC建立为有效的肿瘤抑制因子，参与调节与细胞生长和增殖，侵袭和治疗抵抗有关的途径。哺乳动物CIC的最著名和研究目标是致癌E-26转录因子ETV1 / 4/5，已发现它们在具有CIC畸变的癌症中升高。在这里，我们回顾了CIC在正常哺乳动物发育中的作用，肿瘤发生和肿瘤进展，以及介导它们的功能性相互作用因子。©2020英国和爱尔兰病理学会。由John Wiley＆Sons，Ltd.出版