Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives,Asian Journal of Organic Chemistry

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Stereoselective Thermal Addition of RP and/or SP‐Menthyl‐Deriving Secondary Phosphine Oxides to Active Alkynes, the Mechanism, Stereochemistry and Generation of P,C‐Chirogenic Bis‐Phosphine Derivatives
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-03-02 , DOI: 10.1002/ajoc.202000079
Bing‐Xia Yan ₁ , Hong‐Xing Zheng ₁ , Jing‐Jing Ye ₁ , Mao‐Ran Qiu ₁ , Yu Zhang ₁ , Chang‐Qiu Zhao ₁ , Qiang Li ₁

Affiliation

The additions of R_P‐1 or S_P‐1 to alkynyl esters stereo selectively afforded bis‐phosphinylated derivatives having up to four C‐ and P‐chirogenic centers. The stereochemistry was controlled by kinetic and thermodynamic processes at lower and higher temperature, respectively. At 100 °C, the bis‐adducts were obtained in up to 99% yield and >99 : 1 d.r.

中文翻译：

RP和/或SP衍生于甲基的仲膦氧化物的立体选择性热加成到活性炔烃的过程，机理，立体化学和P，C-致色双膦衍生物的生成

将R _P - 1或S _P - 1加到炔基酯立体上可选择性地提供具有多达四个C和P色原中心的双次膦酰化衍生物。立体化学分别通过在较低和较高温度下的动力学和热力学过程来控制。在100°C时，双收合物的收率高达99％，> 99：1 dr

更新日期：2020-04-21

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