To maintain cellular homeostasis, the endoplasmic reticulum (ER) necessitates a continuous removal of ER fragments via a selective, receptor-mediated, form of autophagy known as ER-phagy. In this issue of The EMBO Journal, Jiang et al (2020) shed light on how the best characterized autophagy receptor FAM134B mediates ER membrane fragmentation, the earliest event during ER-phagy. They propose a dynamic model for FAM134B protein oligomerization and ER membrane scission, which are driven by CAMK2B-mediated phosphorylation of the receptor and are altered in sensory neuropathy.

中文翻译：

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击败ER：对FAM134B功能和调节的新颖见解。

为了维持细胞稳态，内质网（ER）必须通过选择性的，受体介导的自噬形式（称为ER-噬菌体）连续去除ER片段。在本期《 EMBO杂志》中，Jiang等人（2020年）阐明了具有最佳特征的自噬受体FAM134B如何介导ER膜断裂，这是ER吞噬过程中的最早事件。他们提出了FAM134B蛋白寡聚和ER膜断裂的动力学模型，其由CAMK2B介导的受体磷酸化驱动，并在感觉神经病变中发生改变。