AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis that functions to restore the energy balance by phosphorylating its substrates during altered metabolic conditions. AMPK activity is tightly controlled by diverse regulators including its upstream kinases LKB1 and CaMKK2. Recent studies have also identified the localization of AMPK at different intracellular compartments as another key mechanism for regulating AMPK signaling in response to specific stimuli. This review discusses the AMPK signaling associated with different subcellular compartments, including lysosomes, endoplasmic reticulum, mitochondria, Golgi apparatus, nucleus, and cell junctions. Because altered AMPK signaling is associated with various pathologic conditions including cancer, targeting AMPK signaling in different subcellular compartments may present attractive therapeutic approaches for treatment of disease.

中文翻译：

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在亚细胞区室的AMPK信号的空间控制。

AMP激活的蛋白激酶（AMPK）是能量稳态的主要调节剂，其功能是通过在代谢条件改变时通过磷酸化其底物来恢复能量平衡。AMPK的活性受到包括其上游激酶LKB1和CaMKK2在内的各种调节剂的严格控制。最近的研究还确定了AMPK在不同细胞内区室的定位是响应特定刺激调节AMPK信号传导的另一个关键机制。这篇综述讨论了与不同的亚细胞区室相关的AMPK信号传导，包括溶酶体，内质网，线粒体，高尔基体，细胞核和细胞连接。由于AMPK信号的改变与各种病理状况（包括癌症）有关，