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Thermal-Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-02-19 , DOI: 10.1002/adma.201907030 Benhui Hu 1, 2 , Christopher Berkey 3 , Timothy Feliciano 4 , Xiaohong Chen 5 , Zhuyun Li 2 , Chao Chen 2 , Shahrouz Amini 2 , Mui Hoon Nai 6 , Qun-Li Lei 7 , Ran Ni 7 , Juan Wang 2 , Wan Ru Leow 2 , Shaowu Pan 2 , Yong-Qiang Li 2 , Pingqiang Cai 2 , Ali Miserez 2 , Shuzhou Li 2 , Chwee Teck Lim 6 , Yun-Long Wu 5 , Teri W Odom 4 , Reinhold H Dauskardt 3 , Xiaodong Chen 2
Advanced Materials ( IF 27.4 ) Pub Date : 2020-02-19 , DOI: 10.1002/adma.201907030 Benhui Hu 1, 2 , Christopher Berkey 3 , Timothy Feliciano 4 , Xiaohong Chen 5 , Zhuyun Li 2 , Chao Chen 2 , Shahrouz Amini 2 , Mui Hoon Nai 6 , Qun-Li Lei 7 , Ran Ni 7 , Juan Wang 2 , Wan Ru Leow 2 , Shaowu Pan 2 , Yong-Qiang Li 2 , Pingqiang Cai 2 , Ali Miserez 2 , Shuzhou Li 2 , Chwee Teck Lim 6 , Yun-Long Wu 5 , Teri W Odom 4 , Reinhold H Dauskardt 3 , Xiaodong Chen 2
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Bacterial infections remain a leading threat to global health because of the misuse of antibiotics and the rise in drug-resistant pathogens. Although several strategies such as photothermal therapy and magneto-thermal therapy can suppress bacterial infections, excessive heat often damages host cells and lengthens the healing time. Here, a localized thermal managing strategy, thermal-disrupting interface induced mitigation (TRIM), is reported, to minimize intercellular cohesion loss for accurate antibacterial therapy. The TRIM dressing film is composed of alternative microscale arrangement of heat-responsive hydrogel regions and mechanical support regions, which enables the surface microtopography to have a significant effect on disrupting bacterial colonization upon infrared irradiation. The regulation of the interfacial contact to the attached skin confines the produced heat and minimizes the risk of skin damage during thermoablation. Quantitative mechanobiology studies demonstrate the TRIM dressing film with a critical dimension for surface features plays a critical role in maintaining intercellular cohesion of the epidermis during photothermal therapy. Finally, endowing wound dressing with the TRIM effect via in vivo studies in S. aureus infected mice demonstrates a promising strategy for mitigating the side effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future biointerface design for antibacterial therapy.
中文翻译：
热破坏界面可减轻细胞间凝聚力损失，实现精确的局部抗菌治疗。
由于抗生素的滥用和耐药病原体的增加，细菌感染仍然是全球健康的主要威胁。尽管光热疗法和磁热疗法等多种策略可以抑制细菌感染，但过度的热量通常会损害宿主细胞并延长愈合时间。在此，报告了一种局部热管理策略，即热破坏界面诱导缓解（TRIM），以最大限度地减少细胞间凝聚力损失，从而实现准确的抗菌治疗。 TRIM敷料膜由热响应水凝胶区域和机械支撑区域的交替微尺度排列组成，这使得表面微形貌在红外照射下对破坏细菌定植具有显着效果。与附着皮肤的界面接触的调节限制了产生的热量，并最大限度地减少了热消融过程中皮肤损伤的风险。定量力学生物学研究表明，具有关键表面特征尺寸的 TRIM 敷料膜在光热治疗期间维持表皮细胞间凝聚力方面发挥着关键作用。最后，通过对金黄色葡萄球菌感染的小鼠进行体内研究，赋予伤口敷料 TRIM 效应，这表明了一种有前途的策略，可以减轻光热疗法对广谱细菌感染的副作用，促进未来抗菌治疗的生物界面设计。
更新日期：2020-03-24
中文翻译：
热破坏界面可减轻细胞间凝聚力损失，实现精确的局部抗菌治疗。
由于抗生素的滥用和耐药病原体的增加，细菌感染仍然是全球健康的主要威胁。尽管光热疗法和磁热疗法等多种策略可以抑制细菌感染，但过度的热量通常会损害宿主细胞并延长愈合时间。在此，报告了一种局部热管理策略，即热破坏界面诱导缓解（TRIM），以最大限度地减少细胞间凝聚力损失，从而实现准确的抗菌治疗。 TRIM敷料膜由热响应水凝胶区域和机械支撑区域的交替微尺度排列组成，这使得表面微形貌在红外照射下对破坏细菌定植具有显着效果。与附着皮肤的界面接触的调节限制了产生的热量，并最大限度地减少了热消融过程中皮肤损伤的风险。定量力学生物学研究表明，具有关键表面特征尺寸的 TRIM 敷料膜在光热治疗期间维持表皮细胞间凝聚力方面发挥着关键作用。最后，通过对金黄色葡萄球菌感染的小鼠进行体内研究，赋予伤口敷料 TRIM 效应，这表明了一种有前途的策略，可以减轻光热疗法对广谱细菌感染的副作用，促进未来抗菌治疗的生物界面设计。
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