Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster.,Aging Cell

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Sexual dimorphism in the nutritional requirement for adult lifespan in Drosophila melanogaster.
Aging Cell ( IF 8.0 ) Pub Date : 2020-02-18 , DOI: 10.1111/acel.13120
Qi Wu ₁ , Guixiang Yu ₁ , Xingyi Cheng ₁ , Yue Gao ₁ , Xiaolan Fan ₁ , Deying Yang ₁ , Meng Xie ₁ , Tao Wang ₁ , Matthew D W Piper ₂ , Mingyao Yang ₁

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The nutritional requirements of Drosophila have mostly been studied for development and reproduction, but the minimal requirements for adult male and female flies for lifespan have not been established. Following development on a complete diet, we find substantial sex difference in the basic nutritional requirement of adult flies for full length of life. Relative to females, males require less of each nutrient, and for some nutrients that are essential for development, adult males have no requirement at all for lifespan. The most extreme (and surprising) sex differences were that chronic cholesterol and vitamin deficiencies had no effect on the lifespan of adult males, but they greatly decreased lifespan in females. Female oogenesis rather than chromosomal karyotype and mating status is the key cause of this gender difference in life‐sustaining nutritional requirements. These data are important to the way we understand the mechanisms by which diet modifies lifespan.

中文翻译：

果蝇的成年寿命营养需求中的性二态性。

果蝇的营养需求大部分研究了其发育和繁殖，但尚未确定成年雄性和雌性蝇寿命的最低要求。按照完整的饮食习惯进行开发后，我们发现成年果蝇在整个寿命中的基本营养需求存在明显的性别差异。相对于雌性，雄性对每种营养物质的需求较少，对于某些对发育至关重要的营养物质，成年雄性对寿命完全没有要求。最极端（也是令人惊讶的）的性别差异是，慢性胆固醇和维生素缺乏症对成年男性的寿命没有影响，但是却大大降低了女性的寿命。女性的卵子发育而非染色体核型和交配状态是维持生命所需营养中性别差异的主要原因。

更新日期：2020-02-18

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