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Race modifies default mode connectivity in Alzheimer's disease.
Translational Neurodegeneration ( IF 10.8 ) Pub Date : 2020-02-19 , DOI: 10.1186/s40035-020-0186-4
Maria B Misiura 1, 2 , J Christina Howell 2 , Junjie Wu 3 , Deqiang Qiu 3 , Monica W Parker 2 , Jessica A Turner 1 , William T Hu 2
Affiliation  

Background Older African Americans are more likely to develop Alzheimer's disease (AD) than older Caucasians, and this difference cannot be readily explained by cerebrovascular and socioeconomic factors alone. We previously showed that mild cognitive impairment and AD dementia were associated with attenuated increases in the cerebrospinal fluid (CSF) levels of total and phosphorylated tau in African Americans compared to Caucasians, even though there was no difference in beta-amyloid 1-42 level between the two races. Methods We extended our work by analyzing early functional magnetic resonance imaging (fMRI) biomarkers of the default mode network in older African Americans and Caucasians. We calculated connectivity between nodes of the regions belonging to the various default mode network subsystems and correlated these imaging biomarkers with non-imaging biomarkers implicated in AD (CSF amyloid, total tau, and cognitive performance). Results We found that race modifies the relationship between functional connectivity of default mode network subsystems and cognitive performance, tau, and amyloid levels. Conclusion These findings provide further support that race modifies the AD phenotypes downstream from cerebral amyloid deposition, and identifies key inter-subsystem connections for deep imaging and neuropathologic characterization.

中文翻译:

Race 修改了阿尔茨海默病中的默认模式连接。

背景 与年长的白种人相比,年长的非裔美国人更容易患阿尔茨海默病 (AD),而这种差异不能仅通过脑血管和社会经济因素来解释。我们之前的研究表明,与白种人相比,非洲裔美国人的脑脊液 (CSF) 总和磷酸化 tau 水平的轻度增加与轻度认知障碍和 AD 痴呆相关,尽管两者之间的 β-淀粉样蛋白 1-42 水平没有差异。两个种族。方法 我们通过分析老年非裔美国人和高加索人默认模式网络的早期功能磁共振成像 (fMRI) 生物标志物来扩展我们的工作。我们计算了属于各种默认模式网络子系统的区域节点之间的连接性,并将这些成像生物标志物与涉及 AD 的非成像生物标志物(CSF 淀粉样蛋白、总 tau 和认知表现)相关联。结果 我们发现种族改变了默认模式网络子系统的功能连接与认知表现、tau 和淀粉样蛋白水平之间的关系。结论 这些发现进一步支持种族改变脑淀粉样蛋白沉积下游的 AD 表型,并确定了用于深度成像和神经病理学表征的关键子系统间连接。结果 我们发现种族改变了默认模式网络子系统的功能连接与认知表现、tau 和淀粉样蛋白水平之间的关系。结论 这些发现进一步支持种族改变脑淀粉样蛋白沉积下游的 AD 表型,并确定了用于深度成像和神经病理学表征的关键子系统间连接。结果 我们发现种族改变了默认模式网络子系统的功能连接与认知表现、tau 和淀粉样蛋白水平之间的关系。结论 这些发现进一步支持种族改变脑淀粉样蛋白沉积下游的 AD 表型,并确定了用于深度成像和神经病理学表征的关键子系统间连接。
更新日期:2020-04-22
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