当前位置:
X-MOL 学术
›
BMC Oral Health
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Non-significant association between - 330 T/G polymorphism in interleukin-2 gene and chronic periodontitis: findings from a meta-analysis.
BMC Oral Health ( IF 2.9 ) Pub Date : 2020-02-19 , DOI: 10.1186/s12903-020-1034-8 Felipe Rodolfo Pereira da Silva 1, 2 , Juliana Gomes Galeno 3 , Alessandro Luiz Araújo Bentes Leal 2 , Reyce Santos Koga 2 , Nayana Yared Batista 1 , Silvânia da Conceição Furtado 2 , Daniel Fernando Pereira Vasconcelos 3 , Marcelo Diniz Carvalho 4 , José Fernando Marques Barcellos 1, 2
BMC Oral Health ( IF 2.9 ) Pub Date : 2020-02-19 , DOI: 10.1186/s12903-020-1034-8 Felipe Rodolfo Pereira da Silva 1, 2 , Juliana Gomes Galeno 3 , Alessandro Luiz Araújo Bentes Leal 2 , Reyce Santos Koga 2 , Nayana Yared Batista 1 , Silvânia da Conceição Furtado 2 , Daniel Fernando Pereira Vasconcelos 3 , Marcelo Diniz Carvalho 4 , José Fernando Marques Barcellos 1, 2
Affiliation
BACKGROUND
Chronic periodontitis (CP) is an immune-inflammatory disease that promotes tissue damage around the teeth. Among the several inflammatory mediators that orchestrate the periodontitis, there is the interleukin (IL)-2. Genetic variations in IL2 gene may be associated with the risk and severity of the disease. Contrary results are available in the literature with inconclusive findings and none meta-analysis to gather these data.
METHODS
A literature search was performed for studies published before June 11, 2019 in diverse scientific and educational databases. The data was extracted by two investigators and the statistical evaluation was performed by Review Manager statistical program with heterogeneity (I2) and Odds Ratio (OR) with 95% of Confidence Intervals (CI) calculations and a sensitive analysis to assess the accuracy of the obtained results. The publication bias was evaluated by Begg' and Egger's test with Comprehensive meta-analysis software. The value of P < 0.05 was considered as significant.
RESULTS
Five studies were identified in diverse ethnical groups with 1425 participants. The - 330 T/G polymorphism in IL2 gene was not significantly associated with CP in allelic evaluation (P > 0.05) as well as in the genotypic comparisons (P = 0.15). The Begg's test and the linear regression Egger's test did not show any evidence of publication bias risk (P > 0.05) which was corroborated by the absence of obvious asymmetry in Funnel plot graphic.
CONCLUSIONS
This meta-analysis showed a non-significant association between - 330 T/G polymorphism in IL2 gene and CP in any allelic evaluation.
中文翻译:
白细胞介素2基因的-330 T / G多态性与慢性牙周炎之间无显着关联:一项荟萃分析的发现。
背景技术慢性牙周炎(CP)是一种免疫炎性疾病,其促进牙齿周围的组织损伤。在协调牙周炎的几种炎性介质中,有白介素(IL)-2。IL2基因的遗传变异可能与疾病的风险和严重程度有关。文献中有相反的结果,但结论尚无定论,也没有荟萃分析来收集这些数据。方法对2019年6月11日之前发布的研究在各种科学和教育数据库中进行了文献检索。由两名调查人员提取数据,并由Review Manager统计程序进行统计评估,该程序具有95%的置信区间(CI)计算的异质性(I2)和几率(OR)和敏感分析,以评估所得结果的准确性结果。出版物偏倚通过Begg'和Egger's检验,并使用综合荟萃分析软件进行评估。P <0.05的值被认为是显着的。结果确定了五项研究,涉及1425名参与者,涉及不同种族。在等位基因评估中(P> 0.05)以及在基因型比较中(P = 0.15),IL2基因中的-330 T / G多态性与CP无关(P> 0.05)。Begg检验和线性回归Egger检验未显示任何发表偏倚风险的证据(P> 0。05)在漏斗图中不存在明显的不对称性,从而证实了这一点。结论该荟萃分析显示,在任何等位基因评估中,IL2基因的-330 T / G多态性与CP之间无显着关联。
更新日期:2020-02-19
中文翻译:
白细胞介素2基因的-330 T / G多态性与慢性牙周炎之间无显着关联:一项荟萃分析的发现。
背景技术慢性牙周炎(CP)是一种免疫炎性疾病,其促进牙齿周围的组织损伤。在协调牙周炎的几种炎性介质中,有白介素(IL)-2。IL2基因的遗传变异可能与疾病的风险和严重程度有关。文献中有相反的结果,但结论尚无定论,也没有荟萃分析来收集这些数据。方法对2019年6月11日之前发布的研究在各种科学和教育数据库中进行了文献检索。由两名调查人员提取数据,并由Review Manager统计程序进行统计评估,该程序具有95%的置信区间(CI)计算的异质性(I2)和几率(OR)和敏感分析,以评估所得结果的准确性结果。出版物偏倚通过Begg'和Egger's检验,并使用综合荟萃分析软件进行评估。P <0.05的值被认为是显着的。结果确定了五项研究,涉及1425名参与者,涉及不同种族。在等位基因评估中(P> 0.05)以及在基因型比较中(P = 0.15),IL2基因中的-330 T / G多态性与CP无关(P> 0.05)。Begg检验和线性回归Egger检验未显示任何发表偏倚风险的证据(P> 0。05)在漏斗图中不存在明显的不对称性,从而证实了这一点。结论该荟萃分析显示,在任何等位基因评估中,IL2基因的-330 T / G多态性与CP之间无显着关联。