Composite Hydrogels: Prolonged Local In Vivo Delivery of Stimuli‐Responsive Nanogels That Rapidly Release Doxorubicin in Triple‐Negative Breast Cancer Cells (Adv. Healthcare Mater. 4/2020),Advanced Healthcare Materials

当前位置： X-MOL 学术 › Adv. Healthcare Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Composite Hydrogels: Prolonged Local In Vivo Delivery of Stimuli‐Responsive Nanogels That Rapidly Release Doxorubicin in Triple‐Negative Breast Cancer Cells (Adv. Healthcare Mater. 4/2020)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-02-19 , DOI: 10.1002/adhm.202070011
Yi Zhang ₁ , Pere Dosta _{1,

2} , João Conde _{1,

3} , Nuria Oliva ₁ , Mian Wang _{1,

2} , Natalie Artzi _{1,

2,

4}

Affiliation

In article number 1901101 by Natalie Artzi and co‐workers, dual‐sensitive nanogels rapidly dislodge the chemotherapy drug inside cancer cells through pH and redox sensitivities, enabling efficient cancer‐cell killing. Their incorporation into an injectable hydrogel, delivered to tumor‐adjacent areas, enables prolonged release of the nanogels, with instantaneous action once taken up by cancer cells, resulting in increased therapeutic efficacy.

中文翻译：

复合水凝胶：在三阴性乳腺癌细胞中快速释放阿霉素的刺激反应性纳米凝胶的局部局部体内递送（Adv。Healthcare Mater。4/2020）

娜塔莉·阿齐（Natalie Artzi）和同事的文章编号1901101中，双敏感性纳米凝胶通过pH和氧化还原敏感性将化学治疗药物迅速转移到癌细胞内部，从而有效杀死癌细胞。将它们掺入可注射的水凝胶中，然后传递到肿瘤附近区域，可以延长纳米凝胶的释放，一旦被癌细胞吸收，就会立即产生作用，从而提高治疗效果。

更新日期：2020-02-19

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11