Molecular-Imprinting-Based Surface-Enhanced Raman Scattering Sensors.,ACS Sensors

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Molecular-Imprinting-Based Surface-Enhanced Raman Scattering Sensors.
ACS Sensors ( IF 8.2 ) Pub Date : 2020-03-03 , DOI: 10.1021/acssensors.9b02039
Xiaotong Guo _{1,

2} , Jinhua Li _{1,

3} , Maryam Arabi ₁ , Xiaoyan Wang _{1,

4} , Yunqing Wang ₁ , Lingxin Chen _{1,

4,

5}

Affiliation

Molecularly imprinted polymers (MIPs) receive extensive interest, owing to their structure predictability, recognition specificity, and application universality as well as robustness, simplicity, and inexpensiveness. Surface-enhanced Raman scattering (SERS) is regarded as an ideal optical detection candidate for its unique features of fingerprint recognition, nondestructive property, high sensitivity, and rapidity. Accordingly, MIP based SERS (MIP-SERS) sensors have attracted significant research interest for versatile applications especially in the field of chemo- and bioanalysis, showing excellent identification and detection performances. Herein, we comprehensively review the recent advances in MIP-SERS sensors construction and applications, including sensing principles and signal enhancement mechanisms, focusing on novel construction strategies and representative applications. First, the basic structure of the MIP-SERS sensors is briefly outlined. Second, novel imprinting strategies are highlighted, mainly including multifunctional monomer imprinting, dummy template imprinting, living/controlled radical polymerization, and stimuli-responsive imprinting. Third, typical application of MIP-SERS sensors in chemo/bioanalysis is summarized from both small and macromolecular aspects. Lastly, the challenges and perspectives of the MIP-SERS sensors are proposed, orienting sensitivity improvement and application expanding.

中文翻译：

基于分子印迹的表面增强拉曼散射传感器。

分子印迹聚合物（MIP）由于其结构的可预测性，识别专一性和应用通用性以及耐用性，简单性和便宜性而受到广泛关注。表面增强拉曼散射（SERS）具有独特的指纹识别，无损检测，高灵敏度和快速性等特点，因此被认为是理想的光学检测方法。因此，基于MIP的SERS（MIP-SERS）传感器引起了广泛的应用兴趣，特别是在化学和生物分析领域，具有出色的识别和检测性能，在多功能应用领域引起了广泛的研究兴趣。在此，我们全面回顾了MIP-SERS传感器的构造和应用的最新进展，包括传感原理和信号增强机制，专注于新颖的施工策略和代表性应用。首先，简要概述了MIP-SERS传感器的基本结构。其次，重点介绍了新颖的压印策略，主要包括多功能单体压印，虚拟模板压印，活性/受控自由基聚合和刺激响应压印。第三，从小分子和大分子两个方面总结了MIP-SERS传感器在化学/生物分析中的典型应用。最后，提出了MIP-SERS传感器的挑战和展望，以提高灵敏度和扩大应用范围。活性/受控自由基聚合，以及刺激反应性印迹。第三，从小分子和大分子两个方面总结了MIP-SERS传感器在化学/生物分析中的典型应用。最后，提出了MIP-SERS传感器的挑战和展望，以提高灵敏度和扩大应用范围。活性/受控自由基聚合，以及刺激反应性印迹。第三，从小分子和大分子两个方面总结了MIP-SERS传感器在化学/生物分析中的典型应用。最后，提出了MIP-SERS传感器的挑战和展望，以提高灵敏度和扩大应用范围。

更新日期：2020-02-19

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