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Repurposing of Drugs Is a Viable Approach to Develop Therapeutic Strategies against Central Nervous System Related Pathogenic Amoebae.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-02-19 , DOI: 10.1021/acschemneuro.9b00613 Ayaz Anwar 1 , Naveed Ahmed Khan 2 , Ruqaiyyah Siddiqui 2
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-02-19 , DOI: 10.1021/acschemneuro.9b00613 Ayaz Anwar 1 , Naveed Ahmed Khan 2 , Ruqaiyyah Siddiqui 2
Affiliation
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Brain-eating amoebae including Acanthamoeba spp., Naegleria fowleri, and Balamuthia mandrillaris cause rare infections of the central nervous system that almost always result in death. The high mortality rate, lack of interest for drug development from pharmaceutical industries, and no available effective drugs present an alarming challenge. The current drugs employed in the management and therapy of these devastating diseases are amphotericin B, miltefosine, chlorhexidine, pentamidine, and voriconazole which are generally used in combination. However, clinical evidence shows that these drugs have limited efficacy and high host cell cytotoxicity. Repurposing of drugs is a practical approach to utilize commercially available, U.S. Food and Drug Administration approved drugs for one disease against rare diseases caused by brain-eating amoebae. In this Perspective, we highlight some of the success stories of drugs repositioned against neglected parasitic diseases and identify future potential for effective and sustainable drug development against brain-eating amoebae infections.
中文翻译：
药物的重新利用是发展针对中枢神经系统相关病原性变形虫的治疗策略的可行方法。
食虫性变形虫，包括棘形棘阿米巴菌，Naegleria fowleri和Balamuthia mandrillaris导致罕见的中枢神经系统感染，几乎总是导致死亡。高死亡率，制药业对药物开发缺乏兴趣以及没有可用的有效药物提出了令人震惊的挑战。用于治疗和治疗这些毁灭性疾病的当前药物为两性霉素B，米替福辛，洗必泰，喷他idine和伏立康唑，它们通常合用。然而，临床证据表明这些药物具有有限的功效和高的宿主细胞细胞毒性。重新利用药物是一种实用的方法，可以利用市售的，经美国食品和药物管理局批准的药物来治疗一种因食用大脑的变形虫而引起的罕见疾病。从这个角度来看，
更新日期：2020-02-19
中文翻译：
药物的重新利用是发展针对中枢神经系统相关病原性变形虫的治疗策略的可行方法。
食虫性变形虫，包括棘形棘阿米巴菌，Naegleria fowleri和Balamuthia mandrillaris导致罕见的中枢神经系统感染，几乎总是导致死亡。高死亡率，制药业对药物开发缺乏兴趣以及没有可用的有效药物提出了令人震惊的挑战。用于治疗和治疗这些毁灭性疾病的当前药物为两性霉素B，米替福辛，洗必泰，喷他idine和伏立康唑，它们通常合用。然而，临床证据表明这些药物具有有限的功效和高的宿主细胞细胞毒性。重新利用药物是一种实用的方法，可以利用市售的，经美国食品和药物管理局批准的药物来治疗一种因食用大脑的变形虫而引起的罕见疾病。从这个角度来看，
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