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Natural products as modulators of eukaryotic protein secretion.
Natural Product Reports ( IF 10.2 ) Pub Date : 2020-02-18 , DOI: 10.1039/c9np00066f Hendrik Luesch 1 , Ville O Paavilainen
Natural Product Reports ( IF 10.2 ) Pub Date : 2020-02-18 , DOI: 10.1039/c9np00066f Hendrik Luesch 1 , Ville O Paavilainen
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Covering: up to the end of 2019Diverse natural product small molecules have allowed critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically synthesized secretory proteins into their surroundings or to insert newly synthesized integral membrane proteins into the lipid bilayer of the endoplasmic reticulum. In addition, many components of the endoplasmic reticulum, required for protein homeostasis or other processes such as lipid metabolism or maintenance of calcium homeostasis, are being investigated for their potential in modulating human disease conditions such as cancer, neurodegenerative conditions and diabetes. In this review, we cover recent findings up to the end of 2019 on natural products that influence protein secretion or impact ER protein homeostasis, and serve as powerful chemical tools to understand protein flux through the mammalian secretory pathway and as leads for the discovery of new therapeutics.
中文翻译：
天然产物作为真核蛋白质分泌的调节剂。
涵盖范围：截至2019年底，各种天然产物小分子已使人们对控制真核细胞将胞质合成的分泌蛋白分泌到周围环境中或将新合成的整合膜蛋白插入内质网脂质双层中的能力的过程有了深入的了解。此外，正在研究蛋白质稳态或其他过程（如脂质代谢或维持钙稳态）所必需的内质网许多成分在调节人类疾病（如癌症，神经退行性疾病和糖尿病）中的潜力。在这篇评论中，我们涵盖了截至2019年底有关影响蛋白质分泌或影响ER蛋白稳态的天然产物的最新发现，
更新日期：2020-02-18
中文翻译：
天然产物作为真核蛋白质分泌的调节剂。
涵盖范围：截至2019年底，各种天然产物小分子已使人们对控制真核细胞将胞质合成的分泌蛋白分泌到周围环境中或将新合成的整合膜蛋白插入内质网脂质双层中的能力的过程有了深入的了解。此外，正在研究蛋白质稳态或其他过程（如脂质代谢或维持钙稳态）所必需的内质网许多成分在调节人类疾病（如癌症，神经退行性疾病和糖尿病）中的潜力。在这篇评论中，我们涵盖了截至2019年底有关影响蛋白质分泌或影响ER蛋白稳态的天然产物的最新发现，
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