Nitric Oxide-Biosignal-Responsive Polypeptide Nanofilaments,ACS Macro Letters

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Nitric Oxide-Biosignal-Responsive Polypeptide Nanofilaments
ACS Macro Letters ( IF 5.1 ) Pub Date : 2020-02-18 , DOI: 10.1021/acsmacrolett.0c00004
Renjie Liu ₁ , Miaomiao Xu ₁ , Qiang Yan ₁

Affiliation

Nitric oxide (NO) is one of the three gasotransmitters in living organisms that relates to numerous biological signaling processes. The quest to smart molecular self-assembled systems with ideal NO-responsivity enables precise therapy and diagnosis of NO-associated diseases. Here we report a class of amphiphilic polypeptide containing an o-phenylenediamine-functionalized poly(l-glutamate) segment (PEOPA) that can respond to NO biosignal with extraordinary sensitivity and selectivity. Such polypeptides can further form a rigid filament nanostructure via the synergism of an α-helical secondary structure of PEOPA blocks and H-bonding between interchain OPA side groups. A biologically relevant level of NO can cleave the filament-forming OPA motifs, thus, leading to a dissociation of the assemblies. This NO-responsive disassembly behavior makes these polypeptide nanofilaments as NO-activated nanocarriers, which hold promise for NO-pathological milieu-specific drug delivery.

中文翻译：

一氧化氮生物信号响应多肽纳米丝

一氧化氮 (NO) 是生物体中与众多生物信号传导过程相关的三种气体递质之一。对具有理想 NO 响应性的智能分子自组装系统的探索能够实现 NO 相关疾病的精确治疗和诊断。在这里，我们报告了一类含有邻苯二胺官能化聚（l-谷氨酸）片段（PEOPA），可以以非凡的灵敏度和选择性响应 NO 生物信号。这样的多肽可以通过PEOPA嵌段的α-螺旋二级结构和链间OPA侧基之间的氢键的协同作用进一步形成刚性丝状纳米结构。生物学相关水平的 NO 可以切割形成细丝的 OPA 基序，从而导致组件解离。这种对 NO 响应的分解行为使这些多肽纳米丝成为 NO 激活的纳米载体，有望用于 NO 病理环境特异性药物递送。

更新日期：2020-02-18

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