Ruthenium‐Catalyzed meta‐CAr–H Bond Difluoroalkylation of 2‐Phenoxypyridines,European Journal of Organic Chemistry

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Ruthenium‐Catalyzed meta‐CAr–H Bond Difluoroalkylation of 2‐Phenoxypyridines
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2020-03-17 , DOI: 10.1002/ejoc.201901883
Chunqi Jia ₁ , Shichong Wang ₂ , Xulu Lv ₂ , Gang Li ₂ , Lei Zhong ₂ , Lei Zou ₂ , Xiuling Cui ₁

Affiliation

A ruthenium‐catalyzed meta‐selective C_Ar–H bond difluoroalkylation of 2‐phenoxypyridine using 2‐bromo‐2,2‐difluoroacetate has been developed, which provide a new method to synthesize 2‐(meta‐difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.