A series of complexes consisting of natural amino acids and tin (Sn(AA) 2 ) prepared by conventional neutralization reactions were tested as a new class of cost-effective catalysts with high reactivity and low toxicity towards some biocompatible aliphatic polyesters. In our system, by using a simple catalyst and a benzyl alcohol (BnOH) initiator, biocompatible, and biodegradable aliphatic polyesters, such as poly( l -lactide), poly(ε-caprolactone), and poly(trimethylene carbonate), were well prepared. The results demonstrated that Sn(AA) 2 catalysts, especially the phenylalanine-tin complex (Sn(L-Phe) 2 ) ( M n, up to 194 kg/mol), were suitable for the synthesis of moderate and high-molecular weight poly( l -lactide), which exhibited good biocompatibility. Analysis of the backbone structure and end groups of low-molar-mass polymers by using MALDI-TOF mass spectra and 1 H NMR spectroscopy suggested that the reaction proceeds by a dual activation mechanism. Given their low cost, simple preparation, high reactivity, and low toxicity, complexes consisting of natural amino acids and tin are promising for industrial-scale production of biocompatible aliphatic polyesters. A series of complexes consisting of natural amino acids and tin were developed as a new class of cost-effective catalysts with high reactivity and low toxicity towards some biocompatible aliphatic polyesters. The results demonstrated that Sn(AA) 2 catalysts, especially the phenylalanine-tin complex (Sn(L-Phe) 2 ) ( M n , up to 194 kg/mol), were suitable for the synthesis of moderate- and high-molecular-weight poly(L-lactide), which exhibited good biocompatibility.

中文翻译：

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氨基酸与锡络合物作为一类新型催化剂，对生物相容性脂肪族聚酯具有高反应性和低毒性

通过常规中和反应制备的一系列由天然氨基酸和锡 (Sn(AA) 2 ) 组成的配合物被测试为一种新型的具有成本效益的催化剂，对某些生物相容性脂肪族聚酯具有高反应性和低毒性。在我们的系统中，通过使用简单的催化剂和苯甲醇 (BnOH) 引发剂，生物相容性和可生物降解的脂肪族聚酯，如聚（l-丙交酯）、聚（ε-己内酯）和聚（碳酸三亚甲基酯），准备好了。结果表明，Sn(AA) 2 催化剂，特别是苯丙氨酸-锡配合物(Sn(L-Phe) 2 ) (Mn，高达194 kg/mol)，适用于合成中等和高分子量聚（l-丙交酯），表现出良好的生物相容性。使用 MALDI-TOF 质谱和 1 H NMR 光谱分析低摩尔质量聚合物的主链结构和端基表明反应通过双重激活机制进行。鉴于其成本低、制备简单、反应活性高、毒性低，由天然氨基酸和锡组成的复合物有望用于生物相容性脂肪族聚酯的工业规模生产。一系列由天然氨基酸和锡组成的配合物被开发为一类新型的具有成本效益的催化剂，对某些生物相容性脂肪族聚酯具有高反应性和低毒性。结果表明，Sn(AA) 2 催化剂，特别是苯丙氨酸-锡配合物(Sn(L-Phe) 2 ) (Mn，高达194 kg/mol)，适用于合成中、高分子-重量聚（L-丙交酯），