An epigenetic clock for human skeletal muscle.,Journal of Cachexia, Sarcopenia and Muscle

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An epigenetic clock for human skeletal muscle.
Journal of Cachexia, Sarcopenia and Muscle ( IF 9.4 ) Pub Date : 2020-02-17 , DOI: 10.1002/jcsm.12556
Sarah Voisin ₁ , Nicholas R Harvey _{2,

3} , Larisa M Haupt ₃ , Lyn R Griffiths ₃ , Kevin J Ashton ₂ , Vernon G Coffey ₂ , Thomas M Doering _{2,

4} , Jamie-Lee M Thompson ₂ , Christian Benedict ₅ , Jonathan Cedernaes ₆ , Malene E Lindholm ₇ , Jeffrey M Craig _{8,

9} , David S Rowlands ₁₀ , Adam P Sharples _{11,

12} , Steve Horvath ₁₃ , Nir Eynon ₁

Affiliation

Institute for Health and Sport, Victoria University, Melbourne, Australia.
Faculty of Health Sciences & Medicine, Bond University, Gold Coast, Australia.
Genomics Research Centre, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia.
School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Australia.
Sleep Research Laboratory, Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Centre for Molecular and Medical Research, Deakin University, Geelong, Australia.
Epigenetics, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, Australia.
School of Sport, Exercise and Nutrition, Massey University, Wellington, New Zealand.
Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway.
Stem Cells, Ageing and Molecular Physiology Unit, Exercise Metabolism and Adaptation Research Group, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Department of Human Genetics and Biostatistics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the original pan‐tissue epigenetic clock did not include skeletal muscle samples and hence exhibited a strong deviation between DNA methylation and chronological age in this tissue.

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