Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses.,International Journal of Epidemiology

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Body mass index and height and risk of cutaneous melanoma: Mendelian randomization analyses.
International Journal of Epidemiology ( IF 6.4 ) Pub Date : 2020-02-18 , DOI: 10.1093/ije/dyaa009
Jean Claude Dusingize _{1,

2} , Catherine M Olsen _{1,

3} , Jiyuan An ₄ , Nirmala Pandeya _{1,

2} , Matthew H Law ₄ , Bridie S Thompson ₁ , Alisa M Goldstein ₅ , Mark M Iles ₆ , Penelope M Webb _{1,

2} , Rachel E Neale _{1,

2} , Jue-Sheng Ong ₄ , Stuart MacGregor _{3,

4} , David C Whiteman _{1,

2}

Affiliation

Height and body mass index (BMI) have both been positively associated with melanoma risk, although findings for BMI have been less consistent than height. It remains unclear, however, whether these associations reflect causality or are due to residual confounding by environmental and lifestyle risk factors. We re-evaluated these associations using a two-sample Mendelian randomization (MR) approach.

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