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Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells.
ChemPlusChem ( IF 3.0 ) Pub Date : 2020-02-18 , DOI: 10.1002/cplu.201900678
Adhish Singh,Ming Hua Hsu,Neeraj Gupta,Partha Khanra,Pankaj Kumar,Ved Prakash Verma,Mohit Kapoor

The concept of gene vectors for therapeutic applications have been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non‐viral vector for Gene Therapy. This minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants.

中文翻译:

用于哺乳动物和植物细胞基因治疗的衍生碳纳米管。

用于治疗应用的基因载体的概念已为人所知,但还远未揭示其实际潜力。随着中空圆柱状碳纳米材料(例如碳纳米管(CNT))的出现,研究人员发明了几种新工具,可以在哺乳动物和植物细胞的所需作用位点传递基因。功能多样化的简便性使CNT成为迄今为止最适合基因治疗的非病毒载体。这份简短的评论讨论了CNT进行表面修饰的灵活性及其在人类和植物基因治疗中作为有效载体的应用。具体来说,我们将讨论科学界为利用质粒DNA,RNA沉默,自杀基因疗法和植物基因工程进行基因疗法而发明的新工具。另外,
更新日期:2020-02-18
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