The vasculature not only transports oxygenated blood, metabolites, and waste products but also serves as a conduit for hormonal communication between distant tissues. Therefore, it is important to maintain homeostasis within the vasculature. Recent studies have greatly expanded our understanding of the regulation of vasculature development and vascular-related diseases at the epigenetic level, including by protein posttranslational modifications, DNA methylation, and noncoding RNAs. Integrating epigenetic mechanisms into the pathophysiologic conceptualization of complex and multifactorial vascular-related diseases may provide promising therapeutic approaches. Several reviews have presented detailed discussions of epigenetic mechanisms not including histone methylation in vascular biology. In this review, we primarily discuss histone methylation in vascular development and maturity, and in vascular diseases.

中文翻译：

---

组蛋白甲基化与血管生物学

脉管系统不仅运输含氧血液、代谢物和废物，而且还充当远距离组织之间激素交流的管道。因此，维持脉管系统内的稳态很重要。最近的研究极大地扩展了我们对表观遗传水平的脉管系统发育和血管相关疾病调控的理解，包括蛋白质翻译后修饰、DNA 甲基化和非编码 RNA。将表观遗传机制整合到复杂和多因素血管相关疾病的病理生理学概念中可能会提供有希望的治疗方法。一些评论详细讨论了血管生物学中不包括组蛋白甲基化的表观遗传机制。在这次审查中，