Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.,Nature Neuroscience

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Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41593-020-0587-9
Michael A Durante _{1,

2,

3,

4} , Stefan Kurtenbach _{2,

3} , Zoukaa B Sargi _{4,

5} , J William Harbour _{2,

3,

4} , Rhea Choi _{1,

2,

6} , Sarah Kurtenbach _{2,

5} , Garrett M Goss _{2,

5} , Hiroaki Matsunami _{7,

8} , Bradley J Goldstein _{2,

5,

6,

9}

Affiliation

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

中文翻译：

成年人嗅觉神经发生和分化的单细胞分析。

成年人中活跃的神经源性生态位的存在存在争议。我们将注意力集中在人类嗅觉神经上皮上，这是一个为大脑嗅球提供输入的颅外部位。通过对 28,726 个细胞进行单细胞 RNA 测序，我们鉴定出了神经干细胞和神经祖细胞池以及神经元。此外，我们还详细描述了 140 种嗅觉受体的表达。这些来自嗅觉神经上皮生态位的数据提供了证据，表明人类的神经元产生可能会持续数十年。

更新日期：2020-02-17

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