当前位置：
X-MOL 学术
›
Transl. Psychiaty
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety.
Translational Psychiatry ( IF 5.8 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41398-020-0751-8 Nicholas L Balderston 1, 2 , Emily M Beydler 1 , Madeline Goodwin 1 , Zhi-De Deng 3 , Thomas Radman 3 , Bruce Luber 3 , Sarah H Lisanby 3 , Monique Ernst 1 , Christian Grillon 1
Translational Psychiatry ( IF 5.8 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41398-020-0751-8 Nicholas L Balderston 1, 2 , Emily M Beydler 1 , Madeline Goodwin 1 , Zhi-De Deng 3 , Thomas Radman 3 , Bruce Luber 3 , Sarah H Lisanby 3 , Monique Ernst 1 , Christian Grillon 1
Affiliation
|
Anxiety disorders are the most prevalent mental disorders, with few effective neuropharmacological treatments, making treatments development critical. While noninvasive neuromodulation can successfully treat depression, few treatment targets have been identified specifically for anxiety disorders. Previously, we showed that shock threat increases excitability and connectivity of the intraparietal sulcus (IPS). Here we tested the hypothesis that inhibitory repetitive transcranial magnetic stimulation (rTMS) targeting this region would reduce induced anxiety. Subjects were exposed to neutral, predictable, and unpredictable shock threat, while receiving double-blinded, 1 Hz active or sham IPS rTMS. We used global brain connectivity and electric-field modelling to define the single-subject targets. We assessed subjective anxiety with online ratings and physiological arousal with the startle reflex. Startle stimuli (103 dB white noise) probed fear and anxiety during the predictable (fear-potentiated startle, FPS) and unpredictable (anxiety-potentiated startle, APS) conditions. Active rTMS reduced both FPS and APS relative to both the sham and no stimulation conditions. However, the online anxiety ratings showed no difference between the stimulation conditions. These results were not dependent on the laterality of the stimulation, or the subjects' perception of the stimulation (i.e. active vs. sham). Results suggest that reducing IPS excitability during shock threat is sufficient to reduce physiological arousal related to both fear and anxiety, and are consistent with our previous research showing hyperexcitability in this region during threat. By extension, these results suggest that 1 Hz parietal stimulation may be an effective treatment for clinical anxiety, warranting future work in anxiety patients.
中文翻译：
低频顶叶重复经颅磁刺激可减少恐惧和焦虑。
焦虑症是最普遍的精神障碍，有效的神经药理学治疗很少，因此治疗的开发至关重要。虽然无创神经调节可以成功治疗抑郁症，但很少有专门针对焦虑症的治疗目标。以前，我们发现休克威胁会增加顶内沟 (IPS) 的兴奋性和连通性。在这里，我们测试了针对该区域的抑制性重复经颅磁刺激 (rTMS) 会减少诱发焦虑的假设。受试者暴露于中性、可预测和不可预测的电击威胁，同时接受双盲、1 Hz 主动或假 IPS rTMS。我们使用全局大脑连接和电场建模来定义单一主题目标。我们通过在线评分评估主观焦虑，并通过惊吓反射评估生理唤醒。惊吓刺激（103 dB 白噪声）在可预测（恐惧增强惊吓，FPS）和不可预测（焦虑增强惊吓，APS）条件下探测恐惧和焦虑。相对于假刺激和无刺激条件，主动 rTMS 降低了 FPS 和 APS。然而，在线焦虑评级显示刺激条件之间没有差异。这些结果不依赖于刺激的偏侧性，或受试者对刺激的感知（即主动与假）。结果表明，在电击威胁期间降低 IPS 兴奋性足以减少与恐惧和焦虑相关的生理唤醒，并且与我们之前的研究一致，该研究表明该区域在受到威胁时会出现过度兴奋。通过扩展，这些结果表明 1 Hz 顶叶刺激可能是治疗临床焦虑的有效方法，值得未来在焦虑患者中开展工作。
更新日期：2020-02-18
中文翻译：
低频顶叶重复经颅磁刺激可减少恐惧和焦虑。
焦虑症是最普遍的精神障碍，有效的神经药理学治疗很少，因此治疗的开发至关重要。虽然无创神经调节可以成功治疗抑郁症，但很少有专门针对焦虑症的治疗目标。以前，我们发现休克威胁会增加顶内沟 (IPS) 的兴奋性和连通性。在这里，我们测试了针对该区域的抑制性重复经颅磁刺激 (rTMS) 会减少诱发焦虑的假设。受试者暴露于中性、可预测和不可预测的电击威胁，同时接受双盲、1 Hz 主动或假 IPS rTMS。我们使用全局大脑连接和电场建模来定义单一主题目标。我们通过在线评分评估主观焦虑，并通过惊吓反射评估生理唤醒。惊吓刺激（103 dB 白噪声）在可预测（恐惧增强惊吓，FPS）和不可预测（焦虑增强惊吓，APS）条件下探测恐惧和焦虑。相对于假刺激和无刺激条件，主动 rTMS 降低了 FPS 和 APS。然而，在线焦虑评级显示刺激条件之间没有差异。这些结果不依赖于刺激的偏侧性，或受试者对刺激的感知（即主动与假）。结果表明，在电击威胁期间降低 IPS 兴奋性足以减少与恐惧和焦虑相关的生理唤醒，并且与我们之前的研究一致，该研究表明该区域在受到威胁时会出现过度兴奋。通过扩展，这些结果表明 1 Hz 顶叶刺激可能是治疗临床焦虑的有效方法，值得未来在焦虑患者中开展工作。
京公网安备 11010802027423号