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Developmental plasticity allows outside-in immune responses by resident memory T cells
Nature Immunology ( IF 27.7 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41590-020-0607-7
Raissa Fonseca 1, 2 , Lalit K Beura 1, 3 , Clare F Quarnstrom 1 , Hazem E Ghoneim 4, 5 , Yiping Fan 6 , Caitlin C Zebley 4 , Milcah C Scott 1 , Nancy J Fares-Frederickson 1 , Sathi Wijeyesinghe 1 , Emily A Thompson 1 , Henrique Borges da Silva 7 , Vaiva Vezys 1 , Benjamin Youngblood 4 , David Masopust 1
Affiliation  

Central memory T (TCM) cells patrol lymph nodes and perform conventional memory responses on restimulation: proliferation, migration and differentiation into diverse T cell subsets while also self-renewing. Resident memory T (TRM) cells are parked within single organs, share properties with terminal effectors and contribute to rapid host protection. We observed that reactivated TRM cells rejoined the circulating pool. Epigenetic analyses revealed that TRM cells align closely with conventional memory T cell populations, bearing little resemblance to recently activated effectors. Fully differentiated TRM cells isolated from small intestine epithelium exhibited the potential to differentiate into TCM cells, effector memory T cells and TRM cells on recall. Ex-TRM cells, former intestinal TRM cells that rejoined the circulating pool, heritably maintained a predilection for homing back to their tissue of origin on subsequent reactivation and a heightened capacity to redifferentiate into TRM cells. Thus, TRM cells can rejoin the circulation but are advantaged to re-form local TRM when called on.



中文翻译:


发育可塑性允许常驻记忆 T 细胞进行由外而内的免疫反应



中央记忆 T (T CM ) 细胞巡逻淋巴结,并在再刺激时执行传统的记忆反应:增殖、迁移和分化为不同的 T 细胞亚群,同时进行自我更新。常驻记忆 T ( TRM ) 细胞驻留在单个器官内,与末端效应器共享特性,有助于快速保护宿主。我们观察到重新激活的 T RM细胞重新加入循环池。表观遗传学分析表明, TRM细胞与传统记忆 T 细胞群密切相关,与最近激活的效应细胞几乎没有相似之处。从小肠上皮分离的完全分化的 T RM细胞表现出分化为 T CM细胞、效应记忆 T 细胞和回忆时 T RM细胞的潜力。 Ex-T RM细胞,即重新加入循环池的前肠道 T RM细胞,在随后的重新激活中遗传性地保持了回归其起源组织的倾向,并且具有增强的再分化为 T RM细胞的能力。因此, TRM细胞可以重新加入循环,但有利于在需要时重新形成局部TRM

更新日期:2020-02-17
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