Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants,Journal of Perinatology

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Acute kidney injury, fluid balance and risks of intraventricular hemorrhage in premature infants
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41372-020-0613-5
Brittnea Adcock ₁ , Sean Carpenter ₂ , John Bauer ₂ , Peter Giannone ₂ , Aric Schadler ₂ , Aftab Chishti ₂ , Mina Hanna ₂

Affiliation

Objective

Evaluate association between fluid balance and intraventricular hemorrhage (IVH).

Study design

Retrospective review of infants <30 weeks gestation admitted to Kentucky Children’s Hospital Neonatal Intensive Care Unit.

Results

Infants with acute kidney injury (AKI) had a 2.4-fold increased risk of IVH (OR 2.38, 95% CI 1.46–3.87) and a 3.5-fold increased risk of severe IVH (OR 3.45, 95% CI 1.98–6.04). Infants above birthweight on day 4 had a 1.9-fold increased risk of IVH (OR 1.86, 95% CI 1.05–3.27) and a 2.0-fold increased risk of severe IVH (OR 1.96, 95% CI 1.03–3.74). When controlling for confounding factors, infants with AKI or above birthweight on day 4 had a 4.6-fold (aOR 4.60, 95% CI 1.80–11.78) and 3.0-fold (aOR 2.96, 95% CI 1.01–8.65) increased risk of severe IVH, respectively.

Conclusion

Infants with AKI during the first week of life had a higher association of severe IVH even after controlling for confounding factors.

中文翻译：

早产儿急性肾损伤、体液平衡和脑室内出血风险

客观的

评估体液平衡与脑室内出血 (IVH) 之间的关联。

学习规划

对入住肯塔基儿童医院新生儿重症监护室的小于 30 周妊娠的婴儿进行回顾性研究。

结果

急性肾损伤 (AKI) 婴儿的 IVH 风险增加 2.4 倍（OR 2.38，95% CI 1.46-3.87），严重 IVH 风险增加 3.5 倍（OR 3.45，95% CI 1.98-6.04）。第 4 天高于出生体重的婴儿的 IVH 风险增加 1.9 倍（OR 1.86，95% CI 1.05-3.27），严重 IVH 风险增加 2.0 倍（OR 1.96，95% CI 1.03-3.74）。在控制混杂因素时，第 4 天患有 AKI 或高于出生体重的婴儿患严重疾病的风险增加了 4.6 倍（aOR 4.60, 95% CI 1.80–11.78）和 3.0 倍（aOR 2.96, 95% CI 1.01–8.65） IVH，分别。