Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients.,Journal of Human Hypertension

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Hypertensive disorders of pregnancy and risks of adverse pregnancy outcomes: a retrospective cohort study of 2368 patients.
Journal of Human Hypertension ( IF 2.7 ) Pub Date : 2020-02-17 , DOI: 10.1038/s41371-020-0312-x
Xun Li _{1,

2} , Weishe Zhang _{1,

2} , Jianhua Lin ₃ , Huai Liu ₄ , Zujing Yang ₅ , Yincheng Teng ₆ , Jingrui Huang _{1,

2} , Qiaozhen Peng _{1,

2} , Xinxiu Lin _{1,

2} , Jiejie Zhang _{1,

2} , Liangqun Xie _{1,

2} , Yingming Xie _{1,

2} , Yuanqiu Li _{1,

2} , Jiefeng Luo _{1,

2} , Weifang Duan _{1,

2} , Jingfei Chen _{1,

2} , Si Duan _{1,

2}

Affiliation

Hypertensive disorders of pregnancy (HDP) comprise a group of hypertension-related diseases and represent the most common medical disorders in pregnancy. The aim of this study was to investigate the risks of adverse pregnancy outcomes in patients with different types of HDP, including gestational hypertension, chronic hypertension, preeclampsia (PE, early or late onset), PE superimposed on chronic hypertension (superimposed PE), eclampsia, and HELLP syndrome. Data from a multicenter retrospective patient cohort in China were analyzed. Seventeen adverse maternal or perinatal outcomes were evaluated. Logistic regression was used to estimate the risk of adverse outcomes for each HDP subgroups, using the gestational hypertension group as the reference. The final analysis included 2368 patients with HDP. Of these, 39.9% of patients reported at least one adverse pregnancy outcome. Patients with early onset PE had the highest risk for having both adverse maternal and perinatal outcomes (OR = 7.28, 95% CI: 2.68, 19.79). The risk of perinatal death significantly increased in HELLP syndrome, superimposed PE, and early onset PE, (OR = 13.81, 6.32, and 4.84, respectively, p < 0.05) groups. This study highlights that among patients with HDP, those with early onset PE had the highest risk for having both adverse maternal and perinatal outcomes, and patients with HELLP syndrome had the highest risk for perinatal death.

更新日期：2020-02-17

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