Influences of niobium pentoxide on roughness, hydrophilicity, surface energy and protein absorption, and cellular responses to PEEK based composites for orthopedic applications.,Journal of Materials Chemistry B

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Influences of niobium pentoxide on roughness, hydrophilicity, surface energy and protein absorption, and cellular responses to PEEK based composites for orthopedic applications.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/02/15 , DOI: 10.1039/c9tb02456e
Junpeng Ge ₁ , Fan Wang ₁ , Zhiyan Xu ₁ , Xuening Shen ₁ , Chao Gao ₁ , Dongliang Wang ₂ , Gangfeng Hu ₃ , Jinlou Gu ₁ , Tingting Tang ₄ , Jie Wei ₁

Affiliation

To improve the bio-performances of polyetheretherketone (PEEK) for orthopedic applications, submicro-particles of niobium pentoxide (Nb2O5) were synthesized using a sol-gel method, and PEEK/Nb2O5 composites (PNC) with a Nb2O5 content of 25v% (PNC25) and 50v% (PNC50) were fabricated by utilizing a process of pressing-sintering. The results showed that the Nb2O5 particles were not only dispersed in the composites but also exposed on the surface of the composites, which formed submicro-structural surfaces. In addition, the hydrophilicity, surface energy, surface roughness and absorption of proteins of the composites were improved with increasing Nb2O5 content. Moreover, the release of Nb ions with the highest concentration of 5.01 × 10-6 mol L-1 from the composite into the medium displayed no adverse effects on cell proliferation and morphology, indicating no cytotoxicity. Furthermore, compared with PEEK, the composites, especially PNC50, obviously stimulated adhesion and proliferation as well as osteogenic differentiation of bone mesenchymal stem cells of rats. The results suggested that the incorporation of Nb2O5 submicro-particles into PEEK produced novel bioactive composites with improved surface properties, which played important roles in regulating cell behaviors. In conclusion, the composites, especially PNC50 with good cytocompatibility and promotion of cellular responses, exhibited great potential as implantable materials for bone repair.

中文翻译：

五氧化二铌对整形外科应用中PEEK基复合材料的粗糙度，亲水性，表面能和蛋白质吸收以及细胞反应的影响。

为了提高聚醚醚酮（PEEK）在整形外科领域的生物性能，使用溶胶-凝胶法合成了五氧化二铌（Nb2O5）的亚微粒，以及Nb2O5含量为25v％的PEEK / Nb2O5复合材料（PNC）（PNC25 ）和50v％（PNC50）是通过利用压制烧结的方法制造的。结果表明，Nb2O5颗粒不仅分散在复合材料中，而且暴露在复合材料的表面，形成了亚微结构表面。另外，随着Nb2O5含量的增加，复合材料的亲水性，表面能，表面粗糙度和蛋白质的吸收也得到改善。此外，复合物中最高浓度为5.01×10-6 mol L-1的Nb离子向培养基中的释放对细胞增殖和形态没有不利影响，表明没有细胞毒性。此外，与PEEK相比，复合材料，特别是PNC50，明显刺激大鼠骨间充质干细胞的粘附和增殖以及成骨分化。结果表明，将Nb2O5亚微粒掺入PEEK可以生产出具有改善的表面性能的新型生物活性复合材料，这在调节细胞行为方面起着重要作用。总之，复合材料，特别是具有良好细胞相容性和促进细胞应答的PNC50，具有作为骨修复材料的巨大潜力。结果表明，将Nb2O5亚微粒掺入PEEK可以生产出具有改善的表面性能的新型生物活性复合材料，这在调节细胞行为方面起着重要作用。总之，复合材料，特别是具有良好细胞相容性和促进细胞应答的PNC50，具有作为骨修复材料的巨大潜力。结果表明，将Nb2O5亚微粒掺入PEEK可以生产出具有改善的表面性能的新型生物活性复合材料，这在调节细胞行为方面起着重要作用。总之，复合材料，特别是具有良好细胞相容性和促进细胞应答的PNC50，具有作为骨修复材料的巨大潜力。

更新日期：2020-04-01

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