Selective inactivation of Gram-negative bacteria by carbon dots derived from natural biomass: Artemisia argyi leaves,Journal of Materials Chemistry B

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Selective inactivation of Gram-negative bacteria by carbon dots derived from natural biomass: Artemisia argyi leaves
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020/02/15 , DOI: 10.1039/c9tb02735a
Huibo Wang _{1,

2,

3,

4,

5} , Mengling Zhang _{1,

2,

3,

4,

5} , Yurong Ma _{1,

2,

3,

4,

5} , Bo Wang _{1,

2,

3,

4,

5} , Mingwang Shao _{1,

2,

3,

4,

5} , Hui Huang _{1,

2,

3,

4,

5} , Yang Liu _{1,

2,

3,

4,

5} , Zhenhui Kang _{1,

2,

3,

4,

5}

Affiliation

Infections caused by Gram-negative bacteria have been an increasing problem worldwide. Meanwhile, the overuse of traditional antibiotics has caused an emergence of drug resistance. The development of new antibacterial agents, which can cope with the threat from drug-resistant bacteria, is urgently needed. Herein, carbon dots (ACDs) derived from Artemisia argyi leaves were obtained via a smoking simulation method and exhibited selective antibacterial ability of targeting Gram-negative bacteria. The bactericidal efficiency of ACDs (150 μg mL⁻¹) for Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Proteusbacillus vulgaris) can reach 100%, while for Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), ACDs have no significant antibacterial function, indicating that the particles can selectively target specific bacteria. The antibacterial mechanism for ACDs confirmed that ACDs could only damage the cell walls of Gram-negative bacteria but not that of Gram-positive bacteria. Moreover, ACDs can inhibit the activity of cell wall-related enzymes in Gram-negative bacteria by changing the enzymatic secondary structure. This work is of great significance for the development of new antibacterial nanomaterials derived from natural biomass as well as the treatment of infections caused by Gram-negative bacteria.

中文翻译：

天然生物质衍生的碳点选择性灭活革兰氏阴性菌：艾蒿叶

革兰氏阴性细菌引起的感染已成为世界范围内日益严重的问题。同时，过度使用传统抗生素已引起耐药性的出现。迫切需要开发能够应对耐药菌威胁的新型抗菌剂。在此，通过吸烟模拟方法获得了来自艾蒿（Artemisia argyi）叶的碳点（ACD），并具有针对革兰氏阴性细菌的选择性抗菌能力。ACD（150μgmL ^-1）对革兰氏阴性菌（大肠杆菌，铜绿假单胞菌和寻常变形杆菌）的杀菌效率细菌可达到100％，而对于革兰氏阳性细菌（金黄色葡萄球菌和枯草芽孢杆菌），ACD则没有明显的抗菌功能，这表明该颗粒可以选择性地靶向特定细菌。ACDs的抗菌机制证实，ACDs仅能破坏革兰氏阴性细菌的细胞壁，而不会破坏革兰氏阳性细菌的细胞壁。此外，ACD可通过改变酶的二级结构来抑制革兰氏阴性细菌中细胞壁相关酶的活性。这项工作对于开发由天然生物质衍生的新型抗菌纳米材料以及治疗革兰氏阴性细菌引起的感染具有重要意义。

更新日期：2020-04-01

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