18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain.,Organic & Biomolecular Chemistry

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18F-Labeled dihydromethidine: positron emission tomography radiotracer for imaging of reactive oxygen species in intact brain.
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2020/02/17 , DOI: 10.1039/d0ob00126k
Hiromichi Egami ₁ , Satoshi Nakagawa ₁ , Yuki Katsura ₁ , Masakatsu Kanazawa ₂ , Shingo Nishiyama ₂ , Toshihiro Sakai ₃ , Yasushi Arano ₄ , Hideo Tsukada ₂ , Osamu Inoue ₃ , Kenichiro Todoroki ₁ , Yoshitaka Hamashima ₁

Affiliation

Dihydromethidine (DHM) labeled with 18F at the para position of the peripheral benzene ring was designed as a positron emission tomography (PET) radiotracer for non-invasive imaging of reactive oxygen species (ROS). This compound readily crosses the blood-brain barrier and is oxidized by ROS, and the oxidation product is retained intracellularly. PET imaging of ROS-producing rat brain microinfused with sodium nitroprusside identified specific brain regions with high ROS concentrations. This tracer should be useful for studies of the pathophysiological roles of ROS, and in the diagnosis of neurodegenerative diseases.

中文翻译：

18F标签的二氢甲基吡啶：正电子发射断层显像示踪剂，用于对完整大脑中的活性氧进行成像。

在外围苯环对位标记有18 F的二氢二甲基吡啶（DHM）被设计为用于无创成像活性氧（ROS）的正电子发射断层扫描（PET）放射性示踪剂。该化合物容易穿过血脑屏障并被ROS氧化，并且氧化产物保留在细胞内。PET注入ROS的大鼠脑微注入硝普钠的PET成像可确定具有高ROS浓度的特定大脑区域。该示踪剂对于研究ROS的病理生理作用以及诊断神经退行性疾病应该是有用的。

更新日期：2020-04-01

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