2-Dimethylchroman framework occurs in many complex natural and synthetic compounds which show various types of biological activities such as antitumor, anticancer, antihypertensive, antioxidant and antithrombotic. Herein, we report an organocatalytic approach to the synthesis of 2,2-dimethylchromans where tropylium tetrafluoroborate was used as an organic Lewis acid catalyst for metal-free prenylation reactions of phenols. This method was amenable to continuous flow chemistry to enable an inexpensive pathway to access 2,2-dimethylchromans on multiple-gram scale with short reaction times, high efficiencies and simple product purification.

2-Dimethylchroman骨架存在于许多复杂的天然和合成化合物中，这些化合物显示出各种类型的生物活性，例如抗肿瘤，抗癌，抗高血压，抗氧化剂和抗血栓形成。在本文中，我们报告了一种有机催化方法，用于合成2,2-二甲基苯并二氢吡喃，其中四氟硼酸对苯二酚用作有机路易斯酸催化剂，用于苯酚的无金属异戊酸酯化反应。该方法适用于连续流化学法，从而能够以较便宜的途径以数克级的规模获得2,2-二甲基苯并二氢吡喃，且反应时间短，效率高且产品纯化简单。