Objective

Phase-contrast magnetic resonance imaging (PC-MRI) is a non-invasive method used to compute blood flow velocity and volume. This systematic review aims to discuss the current status of renal PC-MRI and provide practical recommendations which could inform future clinical studies and its adoption in clinical practice.

Methodology

A comprehensive search of all the PC-MRI studies in human healthy subjects or patients related to the kidneys was performed.

Results

A total of 39 studies were included in which PC-MRI was used to measure renal blood flow (RBF) alongside other derivative hemodynamic parameters. PC-MRI generally showed good correlation with gold standard methods of RBF measurement, both in vitro and in vivo, and good reproducibility. Despite PC-MRI not being routinely used in clinical practice, there are several clinical studies showing its potential to support diagnosis and monitoring of renal diseases, in particular renovascular disease, chronic kidney disease and autosomal dominant polycystic kidney disease.

Discussion

Renal PC-MRI shows promise as a non-invasive technique to reliably measure RBF, both in healthy volunteers and in patients with renal disease. Future multicentric studies are needed to provide definitive normative ranges and to demonstrate the clinical potential of PC-MRI, likely as part of a multi-parametric renal MRI protocol.

中文翻译：

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相衬磁共振成像评估肾脏灌注：系统评价和声明文件

目的

相衬磁共振成像（PC-MRI）是一种非侵入性方法，用于计算血流速度和体积。本系统综述旨在讨论肾PC-MRI的当前状况，并提供实用建议，这些信息可为将来的临床研究及其在临床实践中的采用提供参考。

方法

对人类健康受试者或肾脏相关患者的所有PC-MRI研究进行了全面搜索。

结果

总共包括39项研究，其中PC-MRI与其他衍生血液动力学参数一起用于测量肾血流量（RBF）。PC-MRI通常显示出与体内和体外RBF黄金测定方法的良好相关性，以及良好的可重复性。尽管PC-MRI在临床实践中并未常规使用，但一些临床研究表明其潜力可支持诊断和监测肾脏疾病，尤其是肾血管疾病，慢性肾脏疾病和常染色体显性多囊肾疾病。

讨论区

肾脏PC-MRI在健康志愿者和肾病患者中显示出作为一种无创技术来可靠地测量RBF的前景。需要未来的多中心研究以提供确定的规范范围并证明PC-MRI的临床潜力，这有可能作为多参数肾脏MRI方案的一部分。