Abstract

Summary

Using data from the Hertfordshire cohort study, this study examined the effect of breastfeeding and bottle feeding on adult lumbar spine and femoral neck bone mineral content (BMC) and bone mineral density (BMD). The type of infant milk feeding was significantly associated with lumbar spine BMD in males.

Introduction

Using data from the Hertfordshire cohort study (HCS), this study aims to examine the effect of infant milk feeding on bone health in later life by comparing the effect of breastfeeding and bottle feeding on lumbar spine and femoral neck BMC and BMD.

Methods

Information about infant milk feeding, birth weight (kg) and weight at 1 (kg) was collected by health visitors between 1931 and 1939 in Hertfordshire. BMC and BMD measurements were taken by DXA scan between 1998 and 2004. Linear regression models adjusted for conditional weight at 1, age at DXA scan, sex, adult BMI, smoking behaviour, alcohol consumption, physical activity, dietary calcium, and prudent diet score.

Results

Infant milk feeding was significantly associated with lumbar spine BMD (b = − 0.028; 95% CI, − 0.055; − 0.000; p value, 0.047) in males. On average, males who consumed breastmilk alternatives in infancy had lower lumbar spine BMD measurements than those who were fed only breastmilk. These associations remained significant in fully adjusted models. There were no significant associations between infant milk feeding and bone health for females.

Conclusions

Significant associations between infant milk feeding and lumbar spine BMD in males indicate that breastmilk may be protective for the bone health of male babies. The evidence presented here underscores the potential lifelong benefits of breastfeeding and may highlight the differences between osteoporotic risk factors for males and females.

中文翻译：

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婴儿喂养和晚年骨骼健康：赫特福德郡队列研究的发现

摘要

概要

使用来自赫特福德郡队列研究的数据，本研究检查了母乳喂养和奶瓶喂养对成人腰椎和股骨颈骨矿物质含量（BMC）和骨矿物质密度（BMD）的影响。男性婴儿喂养方式与腰椎骨密度明显相关。

介绍

利用赫特福德郡队列研究（HCS）的数据，本研究旨在通过比较母乳喂养和奶瓶喂养对腰椎和股骨颈BMC和BMD的影响，来检验婴儿乳喂养对以后骨骼健康的影响。

方法

1931年至1939年间，健康游客收集了有关婴儿奶粉喂养，出生体重（kg）和体重1千克（kg）的信息。在1998年至2004年之间通过DXA扫描对BMC和BMD进行了测量。线性回归模型针对1岁时的条件体重，DXA扫描的年龄，性别，成人BMI，吸烟行为，饮酒，身体活动，饮食钙和审慎的饮食评分进行了调整。 。

结果

男性婴儿喂养与腰椎骨密度显着相关（b  =-0.028； 95％CI，-0.055；-0.000；p值，0.047）。平均而言，在婴儿期食用母乳替代品的男性腰椎BMD测量值低于仅母乳喂养的男性。在完全调整的模型中，这些关联仍然很重要。母乳喂养与女性骨骼健康之间没有显着关联。

结论

男性婴儿喂养与腰椎骨密度之间存在显着联系，表明母乳可能对男性婴儿的骨骼健康具有保护作用。本文提供的证据强调了母乳喂养的潜在终生益处，并可能突出了男性和女性的骨质疏松风险因素之间的差异。