Research has shown a relationship between the exposures to a chemical agent called bisphenol-A (BPA), which is extensively used in the production of polycarbonate plastics and the incidence of cardiovascular diseases. This association is most likely caused by the BPA's ability to disrupt multiple cardiac mechanisms, including mitochondrial functions. Therefore, this study aimed to explore the ability of quercetin (QUER) to limit the cardiotoxic effect of BPA in the rat's cardiac mitochondria. The experiment was carried out on 32 male Wistar rats, which were randomly assigned to four groups. The negative control group received olive oil; the positive control group received olive oil plus BPA (250 mg/kg); the third group received olive oil, BPA, and QUER (75 mg/kg); and the fourth group received olive oil and QUER, all orally for 14 days. The rats were slaughtered 24 h after the last treatment. The measured parameters included creatine kinase-MB (CK-MB) and lactate dehydrogenase (LDH) as the biomarkers of cardiotoxicity, triglyceride (TG), total cholesterol (TC), and low-density and high-density lipoprotein cholesterol (LDL-C and HDL-C) as the measures of dyslipidemia, glutathione (GSH) content, catalase activity (CAT), reactive oxygen species (ROS), lipid peroxidation (LPO), and the level of damage to the mitochondrial membranes as the indicators of the impact of QUER on the BPA cardiotoxic effect. Finally, the rats treated with QUER showed better results in terms of serum CK-MB, serum LDH, serum lipid profile, GSH level, CAT activity, mitochondrial membrane potential (ΔΨm), LPO, and ROS. According to the results, QUER could be used as a protective agent against BPA-induced mitochondrial toxicity.

中文翻译：

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槲皮素对双酚A诱导的大鼠心脏线粒体氧化应激的保护作用。

研究表明，被广泛用于聚碳酸酯塑料生产中的称为双酚A（BPA）的化学物质的暴露与心血管疾病的发病率之间存在关联。这种关联很可能是由BPA破坏多种心脏机制（包括线粒体功能）的能力引起的。因此，本研究旨在探讨槲皮素（QUER）限制BPA对大鼠心脏线粒体的心脏毒性作用的能力。实验是在32只Wistar雄性大鼠上进行的，将其随机分为四组。阴性对照组接受橄榄油。阳性对照组接受橄榄油加BPA（250 mg / kg）；第三组接受橄榄油，BPA和QUER（75 mg / kg）；第四组口服橄榄油和QUER，共口服14天。最后一次治疗后24小时将大鼠处死。测得的参数包括肌酸激酶-MB（CK-MB）和乳酸脱氢酶（LDH）作为心脏毒性的生物标志物，甘油三酸酯（TG），总胆固醇（TC）以及低密度和高密度脂蛋白胆固醇（LDL-C）和HDL-C）作为血脂异常，谷胱甘肽（GSH）含量，过氧化氢酶活性（CAT），活性氧（ROS），脂质过氧化（LPO）和线粒体膜损伤程度的指标，作为血脂异常的指标QUER对BPA心脏毒性作用的影响。最后，用QUER治疗的大鼠在血清CK-MB，血清LDH，血清脂质分布，GSH水平，CAT活性，线粒体膜电位（ΔΨm），LPO和ROS方面显示出更好的结果。根据结果​​，