Biaryl scaffolds are prevalent in natural products and drug molecules, and biaryl-containing compounds have been shown to exhibit diverse and interesting biological activities. To date, numerous synthetic methods, particularly direct C-H bond activation, have been developed for the construction of such scaffolds, due to their interesting structural features and biological profiles. We highlight herein recent advances in the construction of biologically important biaryl fragments through direct C-H bond activation and also demonstrate the application of direct C-H arylation in the total synthesis of biaryl-containing natural products and drug molecules. Selected biaryl-containing compounds.

中文翻译：

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通过直接的CH键激活生物重要的联芳基支架的建设：进展和前景。

联芳基支架普遍存在于天然产物和药物分子中，含联芳基的化合物已显示出多种多样且有趣的生物学活性。迄今为止，由于它们的有趣的结构特征和生物学特性，已经开发出许多合成方法，特别是直接CH键活化来构建这种支架。我们在这里强调通过直接CH键活化在生物学上重要的联芳基片段的构建方面的最新进展，并且还证明了直接CH芳基化在含联芳基的天然产物和药物分子的总合成中的应用。选择的含联芳基的化合物。