In the last decade, adverse outcome pathways have been introduced in the fields of toxicology and risk assessment of chemicals as pragmatic tools with broad application potential. While their use in the pharmaceutical and cosmetics sectors has been well documented, their application in the food area remains largely unexplored. In this respect, an expert group of the International Life Sciences Institute Europe has recently explored the use of adverse outcome pathways in the safety evaluation of food additives. A key activity was the organization of a workshop, gathering delegates from the regulatory, industrial and academic areas, to discuss the potentials and challenges related to the application of adverse outcome pathways in the safety assessment of food additives. The present paper describes the outcome of this workshop followed by a number of critical considerations and perspectives defined by the International Life Sciences Institute Europe expert group.

中文翻译：

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在食品添加剂的安全性评估中使用不良结果途径。

在过去的十年中，不良的结果途径已在毒理学和化学品风险评估领域中被引入，作为具有广泛应用潜力的实用工具。尽管它们在制药和化妆品领域的用途已得到充分证明，但在食品领域的应用仍未得到充分开发。在这方面，欧洲国际生命科学研究所的一个专家小组最近研究了不良后果途径在食品添加剂安全性评估中的使用。一项关键活动是组织研讨会，召集来自监管，工业和学术领域的代表，讨论与不良后果途径在食品添加剂安全性评估中的应用相关的潜力和挑战。