Shape memory polymer (SMP) foams are a promising material for hemostatic dressings due to their biocompatibility, high surface area, excellent shape recovery, and ability to quickly initiate blood clotting. Biodegradable SMP foams could eliminate the need for a secondary removal procedure of hemostatic material from the patients’ wound, further facilitating wound healing. In this study, we developed hydrolytically and oxidatively biodegradable SMP foams by reacting polyols (triethanolamine or glycerol) with 6‐aminocaproic acid or glycine to generate foaming monomers with degradable ester bonds. These monomers were used in foam synthesis to provide highly crosslinked SMP foam structures. The ester‐containing foams showed clinically relevant thermal properties that were comparable to controls and excellent shape recovery within eight min. Triethanolamine‐based ester‐containing foams showed interconnected porous structure along with increased mechanical strength. Faster hydrolytic and oxidative biodegradation rates were achieved in ester‐containing foams in comparison to controls. These biodegradable SMP foams with clinically applicable thermal properties possess great potential as an effective hemostatic device for use in hospitals or on battlefields.

中文翻译：

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可生物降解的形状记忆聚合物泡沫，具有适合止血应用的热性能。


形状记忆聚合物 (SMP) 泡沫由于其生物相容性、高表面积、出色的形状恢复性以及快速启动血液凝固的能力，是一种很有前途的止血敷料材料。可生物降解的 SMP 泡沫可以消除患者伤口二次去除止血材料的需要，进一步促进伤口愈合。在这项研究中，我们通过多元醇（三乙醇胺或甘油）与6-氨基己酸或甘氨酸反应生成具有可降解酯键的发泡单体，开发了可水解和氧化生物降解的SMP泡沫。这些单体用于泡沫合成，以提供高度交联的 SMP 泡沫结构。含酯泡沫显示出与对照泡沫相当的临床相关热性能，并且在八分钟内具有出色的形状恢复。基于三乙醇胺的含酯泡沫显示出互连的多孔结构以及增加的机械强度。与对照相比，含酯泡沫实现了更快的水解和氧化生物降解速率。这些可生物降解的 SMP 泡沫具有临床适用的热性能，作为医院或战场上使用的有效止血装置具有巨大的潜力。