Small-molecule inhibitors get pro-inflammatory TNF into shape.,Nature Reviews Rheumatology

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Small-molecule inhibitors get pro-inflammatory TNF into shape.
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41584-020-0388-2
Savvas N Savvides _{1,

2} , Dirk Elewaut _{1,

3}

Affiliation

Newly discovered small-molecule TNF inhibitors serve as antagonists of pro-inflammatory TNF signalling by uniquely harnessing the conformational plasticity of trimeric TNF. The development of this approach could mark a resurgence of non-biologic modulators of clinically relevant protein–protein interactions in rheumatology.

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