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Small-molecule inhibitors get pro-inflammatory TNF into shape.
Nature Reviews Rheumatology ( IF 29.4 ) Pub Date : 2020-04-01 , DOI: 10.1038/s41584-020-0388-2
Savvas N Savvides 1, 2 , Dirk Elewaut 1, 3
Affiliation  

Newly discovered small-molecule TNF inhibitors serve as antagonists of pro-inflammatory TNF signalling by uniquely harnessing the conformational plasticity of trimeric TNF. The development of this approach could mark a resurgence of non-biologic modulators of clinically relevant protein–protein interactions in rheumatology.

中文翻译:

小分子抑制剂可使促炎性TNF形成。

新发现的小分子TNF抑制剂通过独特地利用三聚体TNF的构象可塑性,充当促炎性TNF信号转导的拮抗剂。这种方法的发展可能标志着风湿病学中临床相关蛋白相互作用的非生物调节剂的兴起。
更新日期:2020-02-14
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