The role of ceramides in metabolic disorders: when size and localization matters.,Nature Reviews Endocrinology

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The role of ceramides in metabolic disorders: when size and localization matters.
Nature Reviews Endocrinology ( IF 31.0 ) Pub Date : 2020-02-14 , DOI: 10.1038/s41574-020-0320-5
Sarah M Turpin-Nolan _{1,

2,

3} , Jens C Brüning _{1,

3,

4,

5}

Affiliation

Ceramide accumulation is a hallmark in the manifestation of numerous obesity-related diseases, such as type 2 diabetes mellitus and atherosclerosis. Until the early 2000s, ceramides were viewed as a homogenous class of sphingolipids. However, it has now become clear that ceramides exert fundamentally different effects depending on the specific fatty acyl chain lengths, which are integrated into ceramides by a group of enzymes known as dihydroceramide synthases. In addition, alterations in ceramide synthesis, trafficking and metabolism in specific cellular compartments exert distinct consequences on metabolic homeostasis. Here, we examine the emerging concept of how the intracellular localization of ceramides with distinct acyl chain lengths can regulate glucose metabolism, thus emphasizing their potential as targets in the development of novel and specific therapies for obesity and obesity-associated diseases.

中文翻译：

神经酰胺在代谢紊乱中的作用：当大小和位置很重要时。

神经酰胺蓄积是许多肥胖相关疾病（例如2型糖尿病和动脉粥样硬化）表现的标志。直到2000年代初，神经酰胺才被视为一类鞘脂。然而，现在已经清楚的是，神经酰胺根据特定的脂肪酰基链长度发挥根本不同的作用，所述脂肪酰基链长度通过称为二氢神经酰胺合酶的一组酶整合到神经酰胺中。另外，特定细胞区室中神经酰胺合成，运输和代谢的改变对代谢稳态具有明显的影响。在这里，我们研究了新兴的概念，即具有不同酰基链长度的神经酰胺在细胞内的定位如何调节葡萄糖代谢，

更新日期：2020-02-14

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