Automated anesthesia systems that continuously monitor cortical excitability (CE) changes to govern drug infusion rates, are desirable. Paired‐pulse transcranial magnetic stimulation (ppTMS), with electromyography (EMG), provides noninvasive CE measures. We tested whether, and with what temporal resolution, ppTMS‐EMG detects dose‐dependent CE in rats anesthetized with continuous intravenous propofol. Motor‐evoked potentials (MEPs) were recorded every 20 seconds as either propofol bolus or change in infusion rate was applied. ppTMS‐derived measures varied in direct proportion to propofol dose with subminute temporal resolution. We conclude that ppTMS‐EMG enables real‐time markers of target engagement by anesthetics that may be incorporated into an automated device.

中文翻译：

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经颅磁刺激可追踪丙泊酚麻醉期间皮层兴奋性的亚分钟变化。

连续监测皮质兴奋性 (CE) 变化以控制药物输注速率的自动化麻醉系统是可取的。双脉冲经颅磁刺激 (ppTMS) 和肌电图 (EMG) 提供无创 CE 测量。我们测试了 ppTMS-EMG 是否以及以何种时间分辨率检测持续静脉注射丙泊酚麻醉的大鼠的剂量依赖性 CE。在应用丙泊酚推注或改变输注速度时，每 20 秒记录一次运动诱发电位 (MEP)。ppTMS 衍生的测量与丙泊酚剂量成正比变化，具有亚分钟时间分辨率。我们得出的结论是，ppTMS-EMG 可以通过麻醉剂实时标记靶标，这些标记可能会被整合到自动化设备中。