Whole-brain radiotherapy (WBRT) has been the cornerstone treatment of patients with multiple brain metastases since its introduction in the 1950s.¹ Today, it remains one of the most commonly delivered oncologic treatments, with > 200,000 patients per year receiving this treatment in the United States.² Historically, the prognosis for these patients was generally poor, with survival measured in weeks to months.^3,4 Despite this, the main utility of WBRT is in its ability to palliate neurologic symptoms, improve neurologic death rates, and reduce intracranial failure.^5,6 In spite of these benefits, the toxicity of WBRT is readily apparent, including fatigue, alopecia, nausea, and cognitive decline.⁷

中文翻译：

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现代时代脑转移患者的神经认知结果：避免海马全脑放疗加美金刚治疗的益处。

自1950年代问世以来，全脑放射疗法（WBRT）一直是治疗多发性脑转移患者的基石。¹今天，它仍然是最常用的肿瘤治疗方法之一，在美国每年有超过20万名患者接受这种治疗方法。²从历史上看，这些患者的预后通常较差，存活期数周至数月不等。^3,4尽管如此，WBRT的主要用途在于缓解神经系统症状，改善神经系统死亡率和减少颅内衰竭的能力。^5,6尽管有这些好处，但WBRT的毒性显而易见，包括疲劳，脱发，恶心和认知能力下降。⁷