BACKGROUND Osteoporosis is a major worldwide health concern. The acquisition of bone mass during growth decreases the risk of osteoporosis later in life. Muscular strength is an important and modifiable factor to improve bone development in this period. OBJECTIVE The aim of this review was to summarize the relationship between muscular strength and bone health. METHODS Cross-sectional data from studies addressing this association from childhood to young adulthood were systematically searched. The DerSimonian and Laird method was used to compute pooled estimates of effect size and respective 95% CI. The meta-analyses were conducted separately for upper limbs or lower limbs muscular strength and for bone regions. Additionally, a regression model was used to estimate the influence of determinants such as age, lean mass, fat mass, height, weight and cardiorespiratory fitness in this association. RESULTS Thirty-nine published studies were included in the systematic review. The pooled effect size for the association of upper limbs muscular strength with upper limbs, spine and total body BMD ranged from 0.70 to 1.07 and with upper limbs, spine and total body BMC ranged from 1.84 to 1.30. The pooled effect size for the association of lower limbs muscular strength with lower limbs, spine and total body BMD ranged from 0.54 to 0.88 and with lower limbs, spine and total body BMC ranged between 0.81 and 0.71. All reported pooled effect size estimates were statistically significant. CONCLUSION This systematic review and meta-analysis supports that muscular strength should be considered as a useful skeletal health marker during development and a target outcome for interventions aimed at improving bone health.

中文翻译：

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从儿童到青年人的肌肉力量与骨骼健康之间的关联：系统评价和荟萃分析。

背景技术骨质疏松症是全世界主要的健康问题。在生长过程中获得骨量降低了生命后期发生骨质疏松的风险。在此期间，肌肉力量是改善骨骼发育的重要且可修改的因素。目的本综述旨在总结肌肉力量与骨骼健康之间的关系。方法系统地研究了从研究到解决从儿童到成年这种关联的横断面数据。使用DerSimonian和Laird方法计算效应量和相应95％CI的合并估计。对上肢或下肢的肌肉力量和骨骼区域分别进行荟萃分析。此外，还使用了回归模型来估算诸如年龄，瘦体重，脂肪质量，身高，体重和心肺健康的关系。结果系统评价纳入了39篇已发表的研究。上肢肌肉力量与上肢，脊柱和全身BMD关联的合并效应大小范围为0.70至1.07，与上肢，脊柱和全身BMC的关联范围为1.84至1.30。下肢肌肉力量与下肢，脊柱和全身BMD关联的合并效应大小范围为0.54至0.88，下肢，脊柱和全身BMC的关联效果范围为0.81至0.71。所有报告的合并效应量估计值均具有统计学意义。