PURPOSE With advances in cancer therapy, reproductive-aged women can look forward to a life post-malignancy. Fortunately, fertility preservation (FP) may provide relief from potential infertility caused by cancer or associated caustic treatments. Outcomes of FP in pre-treatment reproductive-aged women with gliomas have not been previously characterized. METHODS Between 2007 and 2018, 10 patients undergoing FP prior to chemotherapy and/or radiation treatment for gliomas were identified at Brigham and Women's Hospital. They were matched 3:1 to male-factor infertility patients by age ± 1 year. RESULTS Patients with gliomas had significantly lower baseline anti-Müllerian hormone levels than male-factor infertility controls (2.37 vs 5.16 ng/mL, p = 0.002, log transformed). Despite higher starting (350 vs. 240 IU, p = 0.004) and total gonadotropin doses (4270 vs. 2270 IU, p < 0.001) over a similar stimulation duration (12.1 vs. 11.1 days, p = 0.219), cancer patients had lower peak estradiol levels (1420 vs. 2245 pg/mL, p = 0.003). The total number of follicles on the day of trigger (14.1 vs. 15.6, p = 0.284), the number of oocytes retrieved (18.4 vs. 20.5, p = 0.618), and the percentage of mature oocytes (69.9 vs. 73.8%, p = 0.076) were similar between cases and controls. One patient returned for a cryopreserved embryo transfer and delivered a healthy child. CONCLUSIONS Patients undergoing FP prior to chemotherapy and/or radiation for a glioma achieve satisfactory FP outcomes and should be appropriately counseled regarding the opportunity to family-build after treatment.

中文翻译：

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胶质瘤女性的生育力保留结果：一项回顾性病例对照研究。

目的随着癌症治疗的进步，育龄妇女可以期待恶性肿瘤后的生活。幸运的是，保留生育力（FP）可以缓解癌症或相关的苛性疗法引起的潜在不孕症。先前尚无治疗前胶质瘤育龄妇女的FP结果。方法在2007年至2018年之间，布莱根妇女医院（Brigham and Women's Hospital）确定了10例接受了FP化疗和/或放射治疗的神经胶质瘤患者。他们按年龄±1岁与男性不育症患者3：1相匹配。结果神经胶质瘤患者的基线抗苗勒氏激素水平明显低于男性不育对照（2.37 vs 5.16 ng / mL，p = 0.002，经对数转换）。尽管启动较高（350 vs. 240 IU，p = 0。004）和促性腺激素总剂量（4270 vs. 2270 IU，p <0.001）在相似的刺激持续时间内（12.1 vs. 11.1天，p = 0.219），癌症患者的雌二醇峰值水平较低（1420 vs. 2245 pg / mL， p = 0.003）。触发当天的卵泡总数（14.1 vs. 15.6，p = 0.284），收回的卵母细胞数量（18.4 vs. 20.5，p = 0.618）和成熟卵母细胞的百分比（69.9 vs. 73.8％， p = 0.076）在病例和对照之间相似。一名患者返回进行冷冻保存的胚胎移植，并分娩出一个健康的孩子。结论在进行化学疗法和/或放疗后因神经胶质瘤接受FP治疗的患者可达到满意的FP结局，应就治疗后的建立家庭机会进行适当咨询。1天，p = 0.219），癌症患者的雌二醇峰值水平较低（1420对2245 pg / mL，p = 0.003）。触发当天的卵泡总数（14.1 vs. 15.6，p = 0.284），收回的卵母细胞数量（18.4 vs. 20.5，p = 0.618）和成熟卵母细胞的百分比（69.9 vs. 73.8％， p = 0.076）在病例和对照之间相似。一名患者返回进行冷冻保存的胚胎移植，并分娩出一个健康的孩子。结论在进行化学疗法和/或放疗后因神经胶质瘤接受FP治疗的患者可达到满意的FP结局，应就治疗后的建立家庭机会进行适当咨询。1天，p = 0.219），癌症患者的雌二醇峰值水平较低（1420对2245 pg / mL，p = 0.003）。触发当天的卵泡总数（14.1 vs. 15.6，p = 0.284），收回的卵母细胞数量（18.4 vs. 20.5，p = 0.618）和成熟卵母细胞的百分比（69.9 vs. 73.8％， p = 0.076）在病例和对照之间相似。一名患者返回进行冷冻保存的胚胎移植，并分娩出一个健康的孩子。结论在进行化学疗法和/或放疗后因神经胶质瘤接受FP治疗的患者可达到满意的FP结局，应就治疗后的建立家庭机会进行适当咨询。病例和对照组之间，回收的卵母细胞数（18.4 vs. 20.5，p = 0.618）和成熟卵母细胞的百分比（69.9 vs. 73.8％，p = 0.076）相似。一名患者返回进行冷冻保存的胚胎移植，并分娩出一个健康的孩子。结论在进行化学疗法和/或放疗后因神经胶质瘤接受FP治疗的患者可达到满意的FP结局，应就治疗后的建立家庭机会进行适当咨询。病例和对照组之间，回收的卵母细胞数（18.4 vs. 20.5，p = 0.618）和成熟卵母细胞的百分比（69.9 vs. 73.8％，p = 0.076）相似。一名患者返回进行冷冻保存的胚胎移植，并分娩出一个健康的孩子。结论在进行化学疗法和/或放疗后因神经胶质瘤接受FP治疗的患者可达到满意的FP结局，应就治疗后的建立家庭机会进行适当咨询。