Background People with migraine have localised (i.e., cephalic) mechanical sensitivity. There is uncertainty regarding widespread (i.e., extra-cephalic) mechanical sensitivity and variations in mechanical sensitivity throughout the migraine cycle. Therefore, this study aimed (1) to comprehensively assess mechanical sensitivity in both cephalic and extra-cephalic regions during the preictal, ictal, postictal and interictal phases; and (2) to compare these findings with mechanical sensitivity at corresponding time-points and locations in healthy participants. Methods According to sample size calculations, 19 people with migraine and 19 matched healthy volunteers participated in a prospective longitudinal study. Pressure pain thresholds were evaluated in three cephalic regions (temporalis, upper trapezius and C1 paraspinal muscles) and two extra-cephalic regions (extensor carpi radialis and tibialis anterior muscle) with a digital algometer during the four phases of the migraine cycle in people with migraine and at corresponding intervals and locations in healthy participants. Linear mixed model analyses with a random intercept were used. Results People with migraine had increased mechanical sensitivity in cephalic and extra-cephalic regions in all phases of the migraine cycle compared to healthy participants. Furthermore, this mechanical sensitivity was more severe in the preictal, ictal and postictal phase compared to the interictal phase in cephalic and extra-cephalic regions. Conclusion People with migraine have localised as well as widespread mechanical sensitivity compared to healthy participants. This sensitivity is even more pronounced immediately before, during and after a migraine attack.

中文翻译：

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整个偏头痛周期中局部和广泛机械敏感性的波动：一项前瞻性纵向研究


背景 偏头痛患者具有局部（即头部）机械敏感性。关于广泛的（即头外）机械敏感性和整个偏头痛周期中机械敏感性的变化存在不确定性。因此，本研究的目的是：（1）全面评估发作前、发作、发作后和发作间期头侧和头外区域的机械敏感性； (2) 将这些发现与健康参与者在相应时间点和位置的机械敏感性进行比较。方法根据样本量计算，19 名偏头痛患者和 19 名匹配的健康志愿者参与了前瞻性纵向研究。在偏头痛患者偏头痛周期的四个阶段期间，使用数字测痛仪评估三个头侧区域（颞肌、上斜方肌和 C1 椎旁肌）和两个头外区域（桡侧伸肌和胫骨前肌）的压痛阈值并在健康参与者中以相应的时间间隔和地点进行。使用具有随机截距的线性混合模型分析。结果与健康参与者相比，偏头痛患者在偏头痛周期的所有阶段中头侧和头外区域的机械敏感性都有所增加。此外，与头侧和头外区域的发作间期相比，这种机械敏感性在发作前、发作和发作后阶段更为严重。结论 与健康参与者相比，偏头痛患者具有局部和广泛的机械敏感性。这种敏感性在偏头痛发作之前、期间和之后更加明显。