BACKGROUND Non-surgical periodontal therapy (NSPT) known as gold standard treatment in managing periodontitis. The aim of this study was to investigate the response of NSPT in periodontitis subjects who were obese. Clinical parameters of periodontitis, changes in serum resistin and periodontal pathogens in subgingival plaque were compared before and after NSPT in periodontitis subjects who were obese and with normal weight. METHODS A total of 48 periodontitis subjects (obese, n = 18; normal weight, n = 30) were recruited (hereafter will be referred as participants) to participate into a prospective, before and after clinical trial. Obesity status is defined by body mass index (BMI) criteria (obese: ≥30 kg/ m2; normal weight < 25 kg/m2). Visible Plaque Index (VPI), Gingival Bleeding Index (GBI), Probing Pocket Depth (PPD) and Clinical Attachment Loss (CAL) were recorded; and serum and plaque were collected at baseline and following 12 weeks post-NSPT. Serum resistin level was analyzed using enzyme-linked immune-sorbant assay (ELISA), while detection of periodontal pathogens in dental plaque were carried out using real time PCR (qPCR). RESULTS Following NSPT, means VPI and GBI showed significant improvement between obese and normal weight groups (p <  0.05), but no difference in means PPD and CAL was observed between groups. Obesity remained as a predictor for VPI and GBI after adjusting for smoking habit. No significant difference was observed in serum resistin level and mean counts for P. gingivalis, T. forsythia, and P. intermedia between obese and normal weight groups following NSPT. CONCLUSIONS Regardless of obesity status, NSPT has a significant impact on VPI and GBI in periodontitis subjects. However, the impact of NSPT towards serum resistin and periodontal pathogens was non-significant in those with periodontitis. TRIAL REGISTRATION This study followed the Consolidation Standards of Reporting Trials Statement and retrospectively registered on 26/11/2015 at clinicaltrials.gov (No. NCT02618486).

中文翻译：

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非手术牙周治疗对肥胖牙周炎患者血清抵抗素及牙周病原菌的影响


背景 非手术牙周治疗（NSPT）被称为治疗牙周炎的金标准治疗。本研究的目的是调查肥胖牙周炎受试者中 NSPT 的反应。比较肥胖、体重正常的牙周炎受试者NSPT前后牙周炎的临床参数、血清抵抗素和龈下菌斑中牙周病原菌的变化。方法 总共招募了 48 名牙周炎受试者（肥胖，n = 18；正常体重，n = 30）（以下称为参与者）参加前瞻性临床试验之前和之后。肥胖状态由体重指数 (BMI) 标准定义（肥胖：≥30 kg/m2；正常体重< 25 kg/m2）。记录可见牙菌斑指数（VPI）、牙龈出血指数（GBI）、探诊深度（PPD）和临床附着丧失（CAL）；在基线和 NSPT 后 12 周收集血清和斑块。使用酶联免疫吸附测定（ELISA）分析血清抵抗素水平，同时使用实时PCR（qPCR）检测牙菌斑中的牙周病原体。结果 NSPT 后，肥胖组和正常体重组之间的平均 VPI 和 GBI 显示出显着改善 (p < 0.05)，但组间的平均 PPD 和 CAL 没有观察到差异。调整吸烟习惯后，肥胖仍然是 VPI 和 GBI 的预测因子。 NSPT后，肥胖组和正常体重组之间的血清抵抗素水平以及牙龈卟啉单胞菌、连翘连翘和中间连翘的平均计数没有观察到显着差异。结论 无论肥胖状况如何，NSPT 对牙周炎受试者的 VPI 和 GBI 都有显着影响。 然而，NSPT 对牙周炎患者血清抵抗素和牙周病原菌的影响并不显着。试验注册本研究遵循报告试验声明的合并标准，并于2015年11月26日在clinicaltrials.gov进行回顾性注册（编号NCT02618486）。