BACKGROUND Albumin-globulin ratio (AGR), a variable based on serum albumin and non-albumin proteins, has been demonstrated as a predictor of mortality in patients with malignant neoplasm. The aim of this study was to evaluate the prognostic value of AGR on peritoneal dialysis (PD) patients. METHODS We retrospectively analyzed 602 incident PD patients from January 1st, 2008, to December 31st, 2017, at our center and followed them until December 31st, 2018. Kaplan-Meier curves and multivariate Cox regression models were applied to analyze the association between AGR and all-cause of mortality and cardiovascular mortality. RESULTS The median follow-up time was 32.17 (interquartile range = 32.80) months. During follow-up, 131 (21.8%) patients died, including 57 patients (43.5%) who died due to cardiovascular diseases. Kaplan-Meier curves showed that patients with AGR > 1.26 had better rates of survival than those with AGR ≤ 1.25 (p < 0.001). After adjusting for potential confounders, the lower AGR level was significantly associated with an increased all-cause and cardiovascular mortality [hazard ratio (HR): 1.57, 95% confidence interval (CI): 1.07-2.32, p = 0.022 and HR: 2.01, 95% CI: 1.10-3.69, p = 0.023 respectively]. CONCLUSIONS Patients with a low AGR level had an increased all-cause and cardiovascular mortality. AGR may be a useful index in identifying patients on PD at risk for CVD and all-cause of mortality.

中文翻译：

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腹膜透析患者的白蛋白球蛋白比例和死亡率：一项回顾性研究。

背景技术已经证明基于血清白蛋白和非白蛋白蛋白的变量白蛋白-球蛋白比（AGR）可作为恶性肿瘤患者死亡率的预测指标。这项研究的目的是评估AGR对腹膜透析（PD）患者的预后价值。方法回顾性分析我中心自2008年1月1日至2017年12月31日的602例PD患者，并随访至2018年12月31日。应用Kaplan-Meier曲线和多因素Cox回归模型分析AGR与AGR的相关性。死亡率和心血管疾病死亡率的所有原因。结果中位随访时间为32.17个月（四分位间距= 32.80）个月。在随访过程中，有131人（21.8％）的患者死亡，其中57人（43.5％）因心血管疾病而死亡。Kaplan-Meier曲线显示，AGR> 1.26的患者比AGR≤1.25的患者具有更好的生存率（p <0.001）。在调整了潜在的混杂因素后，较低的AGR水平与全因和心血管疾病死亡率显着相关[危险比（HR）：1.57，95％置信区间（CI）：1.07-2.32，p = 0.022和HR：2.01 ，95％CI：1.10-3.69，p = 0.023]。结论AGR水平低的患者全因和心血管疾病死亡率增加。AGR可能是确定PD患者有CVD风险和全因死亡的有用指标。较低的AGR水平与全因和心血管疾病死亡率显着相关[危险比（HR）：1.57，95％置信区间（CI）：1.07-2.32，p = 0.022，HR：2.01，95％CI：1.10 -3.69，p分别为0.023]。结论AGR水平低的患者全因和心血管疾病死亡率增加。AGR可能是确定PD患者有CVD风险和全因死亡的有用指标。较低的AGR水平与全因和心血管疾病死亡率显着相关[危险比（HR）：1.57，95％置信区间（CI）：1.07-2.32，p = 0.022，HR：2.01，95％CI：1.10 -3.69，p = 0.023]。结论AGR水平低的患者全因和心血管疾病死亡率增加。AGR可能是确定PD患者有CVD风险和全因死亡的有用指标。