Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications,ACS Materials Letters

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Polyhedral Oligomeric Silsesquioxanes (POSS)-Based Hybrid Soft Gels: Molecular Design, Material Advantages, and Emerging Applications
ACS Materials Letters ( IF 9.6 ) Pub Date : 2020-02-13 , DOI: 10.1021/acsmaterialslett.9b00491
Huihui Shi ₁ , Jing Yang ₂ , Mingliang You ₃ , Zibiao Li ₄ , Chaobin He _{1,

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Affiliation

Polyhedral oligomeric silsesquioxanes (POSS) represent the new frontier in hybrid materials science and engineering, because of their well-defined nanostructure and unique dual nature combining material properties from both inorganic siloxane cage and organic groups at the periphery. Recent advances in synthetic chemistry, combined with the controlled radical polymerization techniques, have significantly influenced the construction of POSS soft gel as emerging biomaterials and beyond. In this Review, the most recent developments in the design strategies of POSS-based hybrid soft gels are presented, with respect to different functions of architectural POSS, including POSS as a crosslinker, end-cap polymer chain, pendent group, etc. In addition, the insights into the uniqueness of POSS in microstructure and their different organic substituents in the enhancement of the hydrogel performance are illustrated. These sophisticated materials with multiple functions, oriented toward advanced therapeutic applications, are further summarized into several active domains in controlled drug delivery, 3D cell culture, tissue engineering, and wound healing. The recent new applications of using POSS hybrid soft gel in environmental health are also summarized in this Review. Finally, perspectives and challenges related to the further advancement of POSS-based hybrid soft gel materials are discussed.

中文翻译：

基于多面体低聚倍半硅氧烷（POSS）的混合软凝胶：分子设计，材料优势和新兴应用

多面体低聚倍半硅氧烷（POSS）代表了混合材料科学和工程学中的新领域，因为它们定义明确的纳米结构和独特的双重性质结合了无机硅氧烷笼和周围有机基团的材料特性。合成化学的最新进展与可控的自由基聚合技术相结合，已极大地影响了POSS软凝胶作为新兴生物材料及其他材料的构建。在这篇综述中，介绍了基于POSS的混合软凝胶设计策略的最新进展，涉及建筑POSS的不同功能，包括POSS作为交联剂，封端聚合物链，侧基等。，说明了POSS在微观结构中的独特性及其在提高水凝胶性能方面的不同有机取代基的见解。这些针对高级治疗应用的具有多种功能的复杂材料在控制药物输送，3D细胞培养，组织工程和伤口愈合中被进一步概括为几个活性域。本综述还概述了在环境健康中使用POSS混合软凝胶的最新新应用。最后，讨论了与基于POSS的混合软凝胶材料的进一步发展有关的观点和挑战。在控制药物输送，3D细胞培养，组织工程和伤口愈合中，它们被进一步概括为几个活性域。本综述还概述了在环境健康中使用POSS混合软凝胶的最新新应用。最后，讨论了与基于POSS的混合软凝胶材料的进一步发展有关的观点和挑战。在控制药物输送，3D细胞培养，组织工程和伤口愈合中，它们被进一步概括为几个活性域。本综述还概述了在环境健康中使用POSS混合软凝胶的最新新应用。最后，讨论了与基于POSS的混合软凝胶材料的进一步发展有关的观点和挑战。

更新日期：2020-02-13

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