C–H functionalization chemistry is one of the most vibrant research areas within synthetic organic chemistry. While most researchers focus on the development of small-scale batch-type transformations, more recently such transformations have been carried out in flow reactors to explore new chemical space, to boost reactivity or to enable scalability of this important reaction class. Herein, an up-to-date overview of C–H bond functionalization reactions carried out in continuous-flow microreactors is presented. A comprehensive overview of reactions which establish the formal conversion of a C–H bond into carbon–carbon or carbon–heteroatom bonds is provided; this includes metal-assisted C–H bond cleavages, hydrogen atom transfer reactions and C–H bond functionalizations which involve an S_E-type process to aromatic or olefinic systems. Particular focus is devoted to showcase the advantages of flow processing to enhance C–H bond functionalization chemistry. Consequently, it is our hope that this review will serve as a guide to inspire researchers to push the boundaries of C–H functionalization chemistry using flow technology.

C–H功能化化学是合成有机化学中最活跃的研究领域之一。尽管大多数研究人员专注于小批量分批转化的开发，但最近在流动反应器中进行了此类转化，以探索新的化学空间，提高反应活性或实现这一重要反应类别的可扩展性。本文介绍了在连续流微反应器中进行的C–H键官能化反应的最新概述。提供了对反应的全面概述，这些反应建立了CH键到CH-碳键或碳-杂原子键的正式转化；其中包括金属辅助的C–H键断裂，氢原子转移反应和涉及S _E的C–H键官能化型方法制得芳族或烯烃体系。尤其着重展示了流动处理在增强C–H键功能化化学方面的优势。因此，我们希望这篇评论能够成为指导，以激发研究人员使用流动技术突破CH-H功能化化学的界限。