Human parechoviruses (HPeV) of the species Parechovirus A are highly prevalent disease-causing pathogens in children worldwide. HPeVs are capable of causing severe disease in adults as well, but the prevalence in adults may be much lower. The aim of our present study was to determine the prevalence of HPeV in clinical samples from adults sent in for diagnostic procedures in a tertiary hospital in the Netherlands. From a total of 10,645 samples obtained from 6175 patients, 20 samples from 11 patients (0.18%) tested positive for HPeV by RT-PCR. Two patients were positive for HPeV-1, two for HPeV-3, and one for HPeV-6. Six HPeVs could not be typed. Eight of the 11 HPeV-positive patients were immunocompromised. Due to comorbidity, we were unable to attribute the patients' clinical symptoms to the HPeV infection. The HPeV prevalence in adults found in this study is low compared to HPeV prevalence in children. This may be largely explained by the high seropositivity rates in adults, although there could be other mechanisms involved.

中文翻译：

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Parechovirus A在荷兰成年人中盛行。

Parechovirus A物种的人类副病毒（HPeV）是全世界儿童中高度流行的致病性病原体。HPeV也可以在成年人中引起严重的疾病，但是成年人中的患病率可能要低得多。我们本研究的目的是确定在荷兰三级医院进行诊断程序的成人临床样品中HPeV的患病率。在从6175名患者中获得的10,645个样本中，有11名患者（0.18％）的20个样本通过RT-PCR检测为HPeV阳性。2例HPeV-1阳性，2例HPeV-3阳性，1例HPeV-6阳性。无法键入六个HPeV。11名HPeV阳性患者中有8名免疫功能低下。由于合并症，我们无法将患者的临床症状归因于HPeV感染。与儿童HPeV患病率相比，本研究中发现的成年人HPeV患病率低。尽管可能有其他机制参与，但成人的血清阳性率高可能在很大程度上解释了这一点。